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dc.contributor.authorGustafsson, BMen_US
dc.contributor.authorMattsson, Ken_US
dc.contributor.authorBogdanovic, Gen_US
dc.contributor.authorLeijonhufvud, Gen_US
dc.contributor.authorHonkaniemi, Een_US
dc.contributor.authorRamme, Ken_US
dc.contributor.authorFord, AMen_US
dc.date.accessioned2020-08-05T13:27:21Z
dc.date.issued2018-11
dc.identifier.citationPediatric blood & cancer, 2018, 65 (11), pp. e27310 - ?
dc.identifier.issn1545-5009
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3906
dc.identifier.eissn1545-5017
dc.identifier.doi10.1002/pbc.27310
dc.description.abstractSCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL.en_US
dc.formatPrint-Electronic
dc.format.extente27310 - ?
dc.languageeng
dc.language.isoeng
dc.subjectHumansen_US
dc.subjectIntracellular Signaling Peptides and Proteinsen_US
dc.subjectAdolescenten_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectInfanten_US
dc.subjectInfant, Newbornen_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectPrecursor T-Cell Lymphoblastic Leukemia-Lymphomaen_US
dc.titleOrigins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
dc.typeJournal Article
dcterms.dateAccepted2018-06-09
rioxxterms.versionofrecord10.1002/pbc.27310
rioxxterms.licenseref.startdate2018-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPediatric blood & canceren_US
pubs.issue11
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia
pubs.publication-statusPublished
pubs.volume65en_US
pubs.embargo.termsNo embargo
icr.researchteamBiology of Childhood Leukaemiaen_US
dc.contributor.icrauthorFord, Anthonyen


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