dc.contributor.author | Gustafsson, BM | |
dc.contributor.author | Mattsson, K | |
dc.contributor.author | Bogdanovic, G | |
dc.contributor.author | Leijonhufvud, G | |
dc.contributor.author | Honkaniemi, E | |
dc.contributor.author | Ramme, K | |
dc.contributor.author | Ford, AM | |
dc.date.accessioned | 2020-08-05T13:27:21Z | |
dc.date.issued | 2018-11-01 | |
dc.identifier.citation | Pediatric blood & cancer, 2018, 65 (11), pp. e27310 - ? | |
dc.identifier.issn | 1545-5009 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3906 | |
dc.identifier.eissn | 1545-5017 | |
dc.identifier.doi | 10.1002/pbc.27310 | |
dc.description.abstract | SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL. | |
dc.format | Print-Electronic | |
dc.format.extent | e27310 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.subject | Humans | |
dc.subject | Intracellular Signaling Peptides and Proteins | |
dc.subject | Adolescent | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | |
dc.title | Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-06-09 | |
rioxxterms.versionofrecord | 10.1002/pbc.27310 | |
rioxxterms.licenseref.startdate | 2018-11 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Pediatric blood & cancer | |
pubs.issue | 11 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia | |
pubs.publication-status | Published | |
pubs.volume | 65 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Biology of Childhood Leukaemia | |
dc.contributor.icrauthor | Ford, Anthony | |