Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
Date
2018-11-01ICR Author
Author
Gustafsson, BM
Mattsson, K
Bogdanovic, G
Leijonhufvud, G
Honkaniemi, E
Ramme, K
Ford, AM
Type
Journal Article
Metadata
Show full item recordAbstract
SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL.
Collections
Subject
Humans
Intracellular Signaling Peptides and Proteins
Adolescent
Child
Child, Preschool
Infant
Infant, Newborn
Female
Male
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Research team
Biology of Childhood Leukaemia
Language
eng
Date accepted
2018-06-09
License start date
2018-11
Citation
Pediatric blood & cancer, 2018, 65 (11), pp. e27310 - ?
Publisher
Wiley