Detecting gas-induced vasomotor changes via blood oxygenation level-dependent contrast in healthy breast parenchyma and breast carcinoma.
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Date
2016-08-01ICR Author
Author
Wallace, TE
Patterson, AJ
Abeyakoon, O
Bedair, R
Manavaki, R
McLean, MA
O'Connor, JPB
Graves, MJ
Gilbert, FJ
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE: To evaluate blood oxygenation level-dependent (BOLD) contrast changes in healthy breast parenchyma and breast carcinoma during administration of vasoactive gas stimuli. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) was performed at 3T in 19 healthy premenopausal female volunteers using a single-shot fast spin echo sequence to acquire dynamic T2 -weighted images. 2% (n = 9) and 5% (n = 10) carbogen gas mixtures were interleaved with either medical air or oxygen in 2-minute blocks, for four complete cycles. A 12-minute medical air breathing period was used to determine background physiological modulation. Pixel-wise correlation analysis was applied to evaluate response to the stimuli in breast parenchyma and these results were compared to the all-air control. The relative BOLD effect size was compared between two groups of volunteers scanned in different phases of the menstrual cycle. The optimal stimulus design was evaluated in five breast cancer patients. RESULTS: Of the four stimulus combinations tested, oxygen vs. 5% carbogen produced a response that was significantly stronger (P < 0.05) than air-only breathing in volunteers. Subjects imaged during the follicular phase of their cycle when estrogen levels typically peak exhibited a significantly smaller BOLD response (P = 0.01). Results in malignant tissue were variable, with three out of five lesions exhibiting a diminished response to the gas stimulus. CONCLUSION: Oxygen vs. 5% carbogen is the most robust stimulus for inducing BOLD contrast, consistent with the opposing vasomotor effects of these two gases. Measurements may be confounded by background physiological fluctuations and menstrual cycle changes. J. Magn. Reson. Imaging 2016;44:335-345.
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Subject
Breast
Vasomotor System
Humans
Breast Neoplasms
Neovascularization, Pathologic
Oxygen
Magnetic Resonance Imaging
Oximetry
Sensitivity and Specificity
Reproducibility of Results
Adult
Aged
Middle Aged
Female
Research team
Quantitative Biomedical Imaging
Language
eng
Date accepted
2016-01-19
License start date
2016-08
Citation
Journal of magnetic resonance imaging : JMRI, 2016, 44 (2), pp. 335 - 345
Publisher
WILEY-BLACKWELL