Show simple item record

dc.contributor.authorBrownlee, PM
dc.contributor.authorChambers, AL
dc.contributor.authorCloney, R
dc.contributor.authorBianchi, A
dc.contributor.authorDowns, JA
dc.date.accessioned2020-08-14T15:39:41Z
dc.date.issued2014-03-27
dc.identifier.citationCell reports, 2014, 6 (6), pp. 973 - 981
dc.identifier.issn2211-1247
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3972
dc.identifier.eissn2211-1247
dc.identifier.doi10.1016/j.celrep.2014.02.012
dc.description.abstractBAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180. Based on data from yeast, we hypothesized that BAF180 may prevent tumorigenesis by promoting cohesion. Here, we show BAF180 is required for centromeric cohesion in mouse and human cells. Mutations identified in tumor samples are unable to support this activity, and also compromise cohesion-dependent functions in yeast. We provide evidence of genome instability in line with loss of cohesion, and importantly, we find dynamic chromosome instability following DNA damage in cells lacking BAF180. These data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation, uncovering a potent mechanism for its tumor-suppressor activity.
dc.formatPrint-Electronic
dc.format.extent973 - 981
dc.languageeng
dc.language.isoeng
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectAneuploidy
dc.subjectGenomic Instability
dc.subjectHMGB Proteins
dc.subjectNuclear Proteins
dc.subjectTranscription Factors
dc.subjectGene Expression Regulation
dc.titleBAF180 promotes cohesion and prevents genome instability and aneuploidy.
dc.typeJournal Article
dcterms.dateAccepted2014-02-10
rioxxterms.versionofrecord10.1016/j.celrep.2014.02.012
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2014-03-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCell reports
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNot known
icr.researchteamEpigenetics and Genome Stability
dc.contributor.icrauthorDowns, Jessica


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0