Fragment growing to retain or alter the selectivity of anchored kinase hinge-binding fragments
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Date
2014-01-01Author
Allen, CE
Welford, AJ
Matthews, TP
Caldwell, JJ
Collins, I
Type
Journal Article
Metadata
Show full item recordAbstract
<p>The selectivity patterns of kinase hinge-binding fragments can be retained during fragment growing, suggesting a new way to control poly-pharmacology.</p>
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Subject
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
INHIBITORS
DISCOVERY
CANCER
IDENTIFICATION
EVOLUTION
TYROSINE
Research team
Medicinal Chemistry 2
Language
eng
License start date
2014-01-01
Citation
MEDCHEMCOMM, 2014, 5 (2), pp. 180 - 185 (6)
Publisher
ROYAL SOC CHEMISTRY