dc.contributor.author | ENCODE Project Consortium, | |
dc.contributor.author | Snyder, MP | |
dc.contributor.author | Gingeras, TR | |
dc.contributor.author | Moore, JE | |
dc.contributor.author | Weng, Z | |
dc.contributor.author | Gerstein, MB | |
dc.contributor.author | Ren, B | |
dc.contributor.author | Hardison, RC | |
dc.contributor.author | Stamatoyannopoulos, JA | |
dc.contributor.author | Graveley, BR | |
dc.contributor.author | Feingold, EA | |
dc.contributor.author | Pazin, MJ | |
dc.contributor.author | Pagan, M | |
dc.contributor.author | Gilchrist, DA | |
dc.contributor.author | Hitz, BC | |
dc.contributor.author | Cherry, JM | |
dc.contributor.author | Bernstein, BE | |
dc.contributor.author | Mendenhall, EM | |
dc.contributor.author | Zerbino, DR | |
dc.contributor.author | Frankish, A | |
dc.contributor.author | Flicek, P | |
dc.contributor.author | Myers, RM | |
dc.date.accessioned | 2020-10-15T15:06:32Z | |
dc.date.issued | 2020-07-30 | |
dc.identifier.citation | Nature, 2020, 583 (7818), pp. 693 - 698 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4152 | |
dc.identifier.eissn | 1476-4687 | |
dc.identifier.doi | 10.1038/s41586-020-2449-8 | |
dc.description.abstract | The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community. | |
dc.format | Print-Electronic | |
dc.format.extent | 693 - 698 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE RESEARCH | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | ENCODE Project Consortium | |
dc.subject | Chromatin | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Histones | |
dc.subject | Transcription Factors | |
dc.subject | Genomics | |
dc.subject | DNA Methylation | |
dc.subject | Gene Expression Regulation | |
dc.subject | Binding Sites | |
dc.subject | Regulatory Sequences, Nucleic Acid | |
dc.subject | Genome | |
dc.subject | Genome, Human | |
dc.subject | Quality Control | |
dc.subject | Databases, Genetic | |
dc.subject | Molecular Sequence Annotation | |
dc.title | Perspectives on ENCODE. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-05-05 | |
rioxxterms.versionofrecord | 10.1038/s41586-020-2449-8 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-07-29 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature | |
pubs.issue | 7818 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group | |
pubs.publication-status | Published | |
pubs.volume | 583 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Functional Proteomics Group | |
dc.contributor.icrauthor | Wright, James | |
dc.contributor.icrauthor | Choudhary, Jyoti | |