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dc.contributor.authorENCODE Project Consortium,
dc.contributor.authorSnyder, MP
dc.contributor.authorGingeras, TR
dc.contributor.authorMoore, JE
dc.contributor.authorWeng, Z
dc.contributor.authorGerstein, MB
dc.contributor.authorRen, B
dc.contributor.authorHardison, RC
dc.contributor.authorStamatoyannopoulos, JA
dc.contributor.authorGraveley, BR
dc.contributor.authorFeingold, EA
dc.contributor.authorPazin, MJ
dc.contributor.authorPagan, M
dc.contributor.authorGilchrist, DA
dc.contributor.authorHitz, BC
dc.contributor.authorCherry, JM
dc.contributor.authorBernstein, BE
dc.contributor.authorMendenhall, EM
dc.contributor.authorZerbino, DR
dc.contributor.authorFrankish, A
dc.contributor.authorFlicek, P
dc.contributor.authorMyers, RM
dc.date.accessioned2020-10-15T15:06:32Z
dc.date.issued2020-07-30
dc.identifier.citationNature, 2020, 583 (7818), pp. 693 - 698
dc.identifier.issn0028-0836
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4152
dc.identifier.eissn1476-4687
dc.identifier.doi10.1038/s41586-020-2449-8
dc.description.abstractThe Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.
dc.formatPrint-Electronic
dc.format.extent693 - 698
dc.languageeng
dc.language.isoeng
dc.publisherNATURE RESEARCH
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectENCODE Project Consortium
dc.subjectChromatin
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectHistones
dc.subjectTranscription Factors
dc.subjectGenomics
dc.subjectDNA Methylation
dc.subjectGene Expression Regulation
dc.subjectBinding Sites
dc.subjectRegulatory Sequences, Nucleic Acid
dc.subjectGenome
dc.subjectGenome, Human
dc.subjectQuality Control
dc.subjectDatabases, Genetic
dc.subjectMolecular Sequence Annotation
dc.titlePerspectives on ENCODE.
dc.typeJournal Article
dcterms.dateAccepted2020-05-05
rioxxterms.versionofrecord10.1038/s41586-020-2449-8
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-07-29
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature
pubs.issue7818
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group
pubs.publication-statusPublished
pubs.volume583
pubs.embargo.termsNot known
icr.researchteamFunctional Proteomics Group
dc.contributor.icrauthorWright, James
dc.contributor.icrauthorChoudhary, Jyoti


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