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dc.contributor.authorOstrom, QT
dc.contributor.authorEgan, KM
dc.contributor.authorNabors, LB
dc.contributor.authorGerke, T
dc.contributor.authorThompson, RC
dc.contributor.authorOlson, JJ
dc.contributor.authorLaRocca, R
dc.contributor.authorChowdhary, S
dc.contributor.authorEckel-Passow, JE
dc.contributor.authorArmstrong, G
dc.contributor.authorWiencke, JK
dc.contributor.authorBernstein, JL
dc.contributor.authorClaus, EB
dc.contributor.authorIl'yasova, D
dc.contributor.authorJohansen, C
dc.contributor.authorLachance, DH
dc.contributor.authorLai, RK
dc.contributor.authorMerrell, RT
dc.contributor.authorOlson, SH
dc.contributor.authorSadetzki, S
dc.contributor.authorSchildkraut, JM
dc.contributor.authorShete, S
dc.contributor.authorHoulston, RS
dc.contributor.authorJenkins, RB
dc.contributor.authorWrensch, MR
dc.contributor.authorMelin, B
dc.contributor.authorAmos, CI
dc.contributor.authorHuse, JT
dc.contributor.authorBarnholtz-Sloan, JS
dc.contributor.authorBondy, ML
dc.date.accessioned2020-10-26T12:27:05Z
dc.date.issued2020-02
dc.identifier.citationInternational journal of cancer, 2020, 146 (3), pp. 739 - 748
dc.identifier.issn0020-7136
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4197
dc.identifier.eissn1097-0215
dc.identifier.doi10.1002/ijc.32318
dc.description.abstractGlioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. We assessed whether EA was associated with glioma in African Americans and Hispanics. Data were obtained for 832 cases and 675 controls from the Glioma International Case-Control Study and GliomaSE Case-Control Study previously estimated to have <80% EA, or self-identify as non-White. We estimated global and local ancestry using fastStructure and RFMix, respectively, using 1,000 genomes project reference populations. Within groups with ≥40% AA (AFR ≥0.4 ), and ≥15% NAA (AMR ≥0.15 ), genome-wide association between local EA and glioma was evaluated using logistic regression conditioned on global EA for all gliomas. We identified two regions (7q21.11, p = 6.36 × 10 -4 ; 11p11.12, p = 7.0 × 10 -4 ) associated with increased EA, and one associated with decreased EA (20p12.13, p = 0.0026) in AFR ≥0.4 . In addition, we identified a peak at rs1620291 (p = 4.36 × 10 -6 ) in 7q21.3. Among AMR ≥0.15 , we found an association between increased EA in one region (12q24.21, p = 8.38 × 10 -4 ), and decreased EA in two regions (8q24.21, p = 0. 0010; 20q13.33, p = 6.36 × 10 -4 ). No other significant associations were identified. This analysis identified an association between glioma and two regions previously identified in EA populations (8q24.21, 20q13.33) and four novel regions (7q21.11, 11p11.12, 12q24.21 and 20p12.13). The identifications of novel association with EA suggest regions to target for future genetic association studies.
dc.formatPrint-Electronic
dc.format.extent739 - 748
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectGlioma
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk
dc.subjectCase-Control Studies
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMiddle Aged
dc.subjectAfrican Americans
dc.subjectEuropean Continental Ancestry Group
dc.subjectHispanic Americans
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectGenetic Association Studies
dc.titleGlioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics.
dc.typeJournal Article
dcterms.dateAccepted2019-02-14
rioxxterms.versionofrecord10.1002/ijc.32318
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of cancer
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume146
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden


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