Klotho and the Treatment of Human Malignancies.
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Date
2020-06-23ICR Author
Author
Sachdeva, A
Gouge, J
Kontovounisios, C
Nikolaou, S
Ashworth, A
Lim, K
Chong, I
Type
Journal Article
Metadata
Show full item recordAbstract
Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share similar molecular hallmarks. In addition to functioning as a tumour suppressor in numerous solid tumours and haematological malignancies, Klotho represents a candidate therapeutic target for patients with these diseases, the majority of whom have limited treatment options. Here, we examine contemporary evidence evaluating the anti-neoplastic effects of Klotho and describe the modulation of downstream oncogenic signalling pathways, including Wnt/β-catenin, FGF, IGF1, PIK3K/AKT, TGFβ, and the Unfolded Protein Response. We also discuss possible approaches to developing therapeutic Klotho and consider technological advances that may facilitate the delivery of Klotho through gene therapy.
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Research team
Ashworth Collaborators
Language
eng
Date accepted
2020-06-16
License start date
2020-06-23
Citation
Cancers, 2020, 12 (6)
Publisher
MDPI