Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth.
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Date
2020-08-18ICR Author
Author
Hervieu, A
Kermorgant, S
Type
Journal Article
Metadata
Show full item recordAbstract
We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- and phosphatidylinositol 3-kinase (PI3K)-independent but promotes mammalian target of rapamycin (mTOR) signaling through triggering its plasma membrane localization.
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Research team
Signal Transduction & Molecular Pharmacology
Language
eng
License start date
2020-08-18
Citation
Molecular & cellular oncology, 2020, 7 (6), pp. 1803029 - ?
Publisher
TAYLOR & FRANCIS INC