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dc.contributor.authorGlubb, DM
dc.contributor.authorThompson, DJ
dc.contributor.authorAben, KK
dc.contributor.authorAlsulimani, A
dc.contributor.authorAmant, F
dc.contributor.authorAnnibali, D
dc.contributor.authorAttia, J
dc.contributor.authorBarricarte, A
dc.contributor.authorBeckmann, MW
dc.contributor.authorBerchuck, A
dc.contributor.authorBermisheva, M
dc.contributor.authorBernardini, MQ
dc.contributor.authorBischof, K
dc.contributor.authorBjørge, L
dc.contributor.authorBodelon, C
dc.contributor.authorBrand, AH
dc.contributor.authorBrenton, JD
dc.contributor.authorBrinton, LA
dc.contributor.authorBruinsma, F
dc.contributor.authorBuchanan, DD
dc.contributor.authorBurghaus, S
dc.contributor.authorBützow, R
dc.contributor.authorCai, H
dc.contributor.authorCarney, ME
dc.contributor.authorChanock, SJ
dc.contributor.authorChen, C
dc.contributor.authorChen, X
dc.contributor.authorChen, Z
dc.contributor.authorCook, LS
dc.contributor.authorCunningham, JM
dc.contributor.authorDe Vivo, I
dc.contributor.authorDeFazio, A
dc.contributor.authorDoherty, JA
dc.contributor.authorDork, T
dc.contributor.authordu Bois, A
dc.contributor.authorDunning, AM
dc.contributor.authorDurst, M
dc.contributor.authorEdwards, T
dc.contributor.authorEdwards, RP
dc.contributor.authorEkici, AB
dc.contributor.authorEwing, A
dc.contributor.authorFasching, PA
dc.contributor.authorFerguson, S
dc.contributor.authorFlanagan, JM
dc.contributor.authorFostira, F
dc.contributor.authorFountzilas, G
dc.contributor.authorFriedenreich, CM
dc.contributor.authorGao, B
dc.contributor.authorGaudet, MM
dc.contributor.authorGawełko, J
dc.contributor.authorGentry-Maharaj, A
dc.contributor.authorGiles, GG
dc.contributor.authorGlasspool, R
dc.contributor.authorGoodman, MT
dc.contributor.authorGronwald, J
dc.contributor.authorHarris, HR
dc.contributor.authorHarter, P
dc.contributor.authorHein, A
dc.contributor.authorHeitz, F
dc.contributor.authorHildebrandt, MAT
dc.contributor.authorHillemanns, P
dc.contributor.authorHøgdall, E
dc.contributor.authorHøgdall, CK
dc.contributor.authorHolliday, EG
dc.contributor.authorHuntsman, DG
dc.contributor.authorHuzarski, T
dc.contributor.authorJakubowska, A
dc.contributor.authorJensen, A
dc.contributor.authorJones, ME
dc.contributor.authorKarlan, BY
dc.contributor.authorKarnezis, A
dc.contributor.authorKelley, JL
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKilleen, JL
dc.contributor.authorKjaer, SK
dc.contributor.authorKlapdor, R
dc.contributor.authorKöbel, M
dc.contributor.authorKonopka, B
dc.contributor.authorKonstantopoulou, I
dc.contributor.authorKopperud, RK
dc.contributor.authorKoti, M
dc.contributor.authorKraft, P
dc.contributor.authorKupryjanczyk, J
dc.contributor.authorLambrechts, D
dc.contributor.authorLarson, MC
dc.contributor.authorLe Marchand, L
dc.contributor.authorLele, S
dc.contributor.authorLester, J
dc.contributor.authorLi, AJ
dc.contributor.authorLiang, D
dc.contributor.authorLiebrich, C
dc.contributor.authorLipworth, L
dc.contributor.authorLissowska, J
dc.contributor.authorLu, L
dc.contributor.authorLu, KH
dc.contributor.authorMacciotta, A
dc.contributor.authorMattiello, A
dc.contributor.authorMay, T
dc.contributor.authorMcAlpine, JN
dc.contributor.authorMcGuire, V
dc.contributor.authorMcNeish, IA
dc.contributor.authorMenon, U
dc.contributor.authorModugno, F
dc.contributor.authorMoysich, KB
dc.contributor.authorNevanlinna, H
dc.contributor.authorOdunsi, K
dc.contributor.authorOlsson, H
dc.contributor.authorOrsulic, S
dc.contributor.authorOsorio, A
dc.contributor.authorPalli, D
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPearce, CL
dc.contributor.authorPejovic, T
dc.contributor.authorPermuth, JB
dc.contributor.authorPodgorska, A
dc.contributor.authorRamus, SJ
dc.contributor.authorRebbeck, TR
dc.contributor.authorRiggan, MJ
dc.contributor.authorRisch, HA
dc.contributor.authorRothstein, JH
dc.contributor.authorRunnebaum, IB
dc.contributor.authorScott, RJ
dc.contributor.authorSellers, TA
dc.contributor.authorSenz, J
dc.contributor.authorSetiawan, VW
dc.contributor.authorSiddiqui, N
dc.contributor.authorSieh, W
dc.contributor.authorSpiewankiewicz, B
dc.contributor.authorSutphen, R
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorSzafron, LM
dc.contributor.authorTeo, SH
dc.contributor.authorThompson, PJ
dc.contributor.authorThomsen, LCV
dc.contributor.authorTitus, L
dc.contributor.authorTone, A
dc.contributor.authorTumino, R
dc.contributor.authorTurman, C
dc.contributor.authorVanderstichele, A
dc.contributor.authorVelez Edwards, D
dc.contributor.authorVergote, I
dc.contributor.authorVierkant, RA
dc.contributor.authorWang, Z
dc.contributor.authorWang-Gohrke, S
dc.contributor.authorWebb, PM
dc.contributor.authorWhite, E
dc.contributor.authorWhittemore, AS
dc.contributor.authorWinham, SJ
dc.contributor.authorWu, X
dc.contributor.authorWu, AH
dc.contributor.authorYannoukakos, D
dc.contributor.authorSpurdle, AB
dc.contributor.authorO'Mara, TA
dc.date.accessioned2021-01-28T10:50:37Z
dc.date.available2021-01-28T10:50:37Z
dc.date.issued2020-11-03
dc.identifier.citationCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020
dc.identifier.issn1055-9965
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4325
dc.identifier.eissn1538-7755
dc.identifier.doi10.1158/1055-9965.epi-20-0739
dc.description.abstractBACKGROUND:Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers. METHODS:Using LDScore regression, we explored the genetic correlation between endometrial cancer and ovarian cancer. To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e. inverse-variance meta-analysis, co-localization, and M-values), and performed analyses stratified by subtype. Candidate target genes were then prioritized using functional genomic data. RESULTS:Genetic correlation analysis revealed significant genetic correlation between the two cancers (rG = 0.43, P = 2.66 × 10-5). We found seven loci associated with risk for both cancers (PBonferroni < 2.4 × 10-9). In addition, four novel sub-genome wide regions at 7p22.2, 7q22.1, 9p12 and 11q13.3 were identified (P < 5 × 10-7). Promoter-associated HiChIP chromatin loops from immortalized endometrium and ovarian cell lines, and expression quantitative trait loci (eQTL) data highlighted candidate target genes for further investigation. CONCLUSION:Using cross-cancer GWAS meta-analysis, we have identified several joint endometrial and ovarian cancer risk loci and candidate target genes for future functional analysis. IMPACT:Our research highlights the shared genetic relationship between endometrial cancer and ovarian cancer. Further studies in larger sample sets are required to confirm our findings.
dc.formatPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleCross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers.
dc.typeJournal Article
dcterms.dateAccepted2020-10-22
rioxxterms.versionAM
rioxxterms.versionofrecord10.1158/1055-9965.epi-20-0739
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2020-11-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorJones, Michaelen


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