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dc.contributor.authorJohnson, N
dc.contributor.authorMaguire, S
dc.contributor.authorMorra, A
dc.contributor.authorKapoor, PM
dc.contributor.authorTomczyk, K
dc.contributor.authorJones, ME
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorGilham, C
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorDennis, J
dc.contributor.authorAhearn, TU
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorAugustinsson, A
dc.contributor.authorBaynes, C
dc.contributor.authorFreeman, LEB
dc.contributor.authorBeckmann, MW
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBlomqvist, C
dc.contributor.authorBoeckx, B
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBurwinkel, B
dc.contributor.authorCampa, D
dc.contributor.authorCanzian, F
dc.contributor.authorCastelao, JE
dc.contributor.authorChanock, SJ
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorClarke, CL
dc.contributor.authorNBCS Collaborators
dc.contributor.authorConroy, DM
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDörk, T
dc.contributor.authorEliassen, AH
dc.contributor.authorEngel, C
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFloris, G
dc.contributor.authorFlyger, H
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGoldberg, MS
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorAOCS Group
dc.contributor.authorGuénel, P
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHarrington, PA
dc.contributor.authorHart, SN
dc.contributor.authorHooning, MJ
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, A
dc.contributor.authorHunter, DJ
dc.contributor.authorABCTB Investigators
dc.contributor.authorkConFab Investigators
dc.contributor.authorJager, A
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorKaaks, R
dc.contributor.authorKeeman, R
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKitahara, CM
dc.contributor.authorKosma, V-M
dc.contributor.authorKoutros, S
dc.contributor.authorKraft, P
dc.contributor.authorKristensen, VN
dc.contributor.authorKurian, AW
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLinet, M
dc.contributor.authorLubiński, J
dc.contributor.authorMannermaa, A
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMartens, JWM
dc.contributor.authorMavroudis, D
dc.contributor.authorMayes, R
dc.contributor.authorMeindl, A
dc.contributor.authorMilne, RL
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewman, WG
dc.contributor.authorNielsen, SF
dc.contributor.authorNordestgaard, BG
dc.contributor.authorObi, N
dc.contributor.authorOlshan, AF
dc.contributor.authorOlson, JE
dc.contributor.authorOlsson, H
dc.contributor.authorOrban, E
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPeterlongo, P
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPylkäs, K
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorRuddy, KJ
dc.contributor.authorSaloustros, E
dc.contributor.authorSandler, DP
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmutzler, RK
dc.contributor.authorScott, C
dc.contributor.authorShu, X-O
dc.contributor.authorSimard, J
dc.contributor.authorSmichkoska, S
dc.contributor.authorSohn, C
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorStone, J
dc.contributor.authorTamimi, RM
dc.contributor.authorTaylor, JA
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTroester, MA
dc.contributor.authorTruong, T
dc.contributor.authorVachon, CM
dc.contributor.authorvan Veen, EM
dc.contributor.authorWang, SS
dc.contributor.authorWeinberg, CR
dc.contributor.authorWendt, C
dc.contributor.authorWildiers, H
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorZheng, W
dc.contributor.authorZiogas, A
dc.contributor.authorDunning, AM
dc.contributor.authorPharoah, PDP
dc.contributor.authorEaston, DF
dc.contributor.authorHowie, AF
dc.contributor.authorPeto, J
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorChang-Claude, J
dc.contributor.authorSchmidt, MK
dc.contributor.authorOrr, N
dc.contributor.authorFletcher, O
dc.coverage.spatialEngland
dc.date.accessioned2021-02-09T11:16:53Z
dc.date.available2021-02-09T11:16:53Z
dc.date.issued2021-01-26
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33495599
dc.identifier10.1038/s41416-020-01185-w
dc.identifier.citationBr J Cancer, 2021
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4339
dc.identifier.eissn1532-1827
dc.identifier.doi10.1038/s41416-020-01185-w
dc.description.abstractBACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. METHODS: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. RESULTS: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10-8). CONCLUSIONS: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
dc.typeJournal Article
dcterms.dateAccepted2020-11-05
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/s41416-020-01185-w
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-01-26
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBr J Cancer
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished online
pubs.embargo.termsNo embargo
icr.researchteamFunctional Genetic Epidemiology
icr.researchteamAetiological Epidemiology
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorJohnson, Nicholaen
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorJones, Michaelen


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