dc.contributor.author | Johnson, N | |
dc.contributor.author | Maguire, S | |
dc.contributor.author | Morra, A | |
dc.contributor.author | Kapoor, PM | |
dc.contributor.author | Tomczyk, K | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Gilham, C | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Ahearn, TU | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Antonenkova, NN | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Aronson, KJ | |
dc.contributor.author | Augustinsson, A | |
dc.contributor.author | Baynes, C | |
dc.contributor.author | Freeman, LEB | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Bermisheva, M | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Boeckx, B | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Campa, D | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Clarke, CL | |
dc.contributor.author | NBCS Collaborators, | |
dc.contributor.author | Conroy, DM | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Eliassen, AH | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Floris, G | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | AOCS Group, | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Harrington, PA | |
dc.contributor.author | Hart, SN | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Howell, A | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | ABCTB Investigators, | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Jager, A | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | John, EM | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Kitahara, CM | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Kurian, AW | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Linet, M | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Martens, JWM | |
dc.contributor.author | Mavroudis, D | |
dc.contributor.author | Mayes, R | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Newman, WG | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Obi, N | |
dc.contributor.author | Olshan, AF | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Orban, E | |
dc.contributor.author | Park-Simon, T-W | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Plaseska-Karanfilska, D | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Rennert, HS | |
dc.contributor.author | Ruddy, KJ | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sandler, DP | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Scott, C | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Smichkoska, S | |
dc.contributor.author | Sohn, C | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Spinelli, JJ | |
dc.contributor.author | Stone, J | |
dc.contributor.author | Tamimi, RM | |
dc.contributor.author | Taylor, JA | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Troester, MA | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Vachon, CM | |
dc.contributor.author | van Veen, EM | |
dc.contributor.author | Wang, SS | |
dc.contributor.author | Weinberg, CR | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Howie, AF | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Fletcher, O | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2021-02-09T11:16:53Z | |
dc.date.available | 2021-02-09T11:16:53Z | |
dc.date.issued | 2021-02-16 | |
dc.identifier | https://www.ncbi.nlm.nih.gov/pubmed/33495599 | |
dc.identifier | 10.1038/s41416-020-01185-w | |
dc.identifier.citation | Br J Cancer, 2021 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4339 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/s41416-020-01185-w | |
dc.description.abstract | BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. METHODS: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. RESULTS: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10-8). CONCLUSIONS: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women. | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGERNATURE | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-11-05 | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1038/s41416-020-01185-w | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-01-26 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Br J Cancer | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published online | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Johnson, Nichola | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Fletcher, Olivia | |