dc.contributor.author | Lesseur, C | |
dc.contributor.author | Ferreiro-Iglesias, A | |
dc.contributor.author | McKay, JD | |
dc.contributor.author | Bossé, Y | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Gaborieau, V | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Christiani, DC | |
dc.contributor.author | Caporaso, NC | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Amos, CI | |
dc.contributor.author | Shete, S | |
dc.contributor.author | Liu, G | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Aldrich, MC | |
dc.contributor.author | Tardon, A | |
dc.contributor.author | Chen, C | |
dc.contributor.author | Triantafillos, L | |
dc.contributor.author | Field, JK | |
dc.contributor.author | Teare, MD | |
dc.contributor.author | Kiemeney, LA | |
dc.contributor.author | Diergaarde, B | |
dc.contributor.author | Ferris, RL | |
dc.contributor.author | Zienolddiny, S | |
dc.contributor.author | Lam, S | |
dc.contributor.author | Olshan, AF | |
dc.contributor.author | Weissler, MC | |
dc.contributor.author | Lacko, M | |
dc.contributor.author | Risch, A | |
dc.contributor.author | Bickeböller, H | |
dc.contributor.author | Ness, AR | |
dc.contributor.author | Thomas, S | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Schabath, MB | |
dc.contributor.author | Wünsch-Filho, V | |
dc.contributor.author | Tajara, EH | |
dc.contributor.author | Andrew, AS | |
dc.contributor.author | Clifford, GM | |
dc.contributor.author | Lazarus, P | |
dc.contributor.author | Grankvist, K | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Arnold, S | |
dc.contributor.author | Melander, O | |
dc.contributor.author | Brunnström, H | |
dc.contributor.author | Boccia, S | |
dc.contributor.author | Cadoni, G | |
dc.contributor.author | Timens, W | |
dc.contributor.author | Obeidat, M | |
dc.contributor.author | Xiao, X | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Hung, RJ | |
dc.contributor.author | Brennan, P | |
dc.date.accessioned | 2021-03-22T10:15:21Z | |
dc.date.available | 2021-03-22T10:15:21Z | |
dc.date.issued | 2021-03-05 | |
dc.identifier.citation | PLoS genetics, 2021, 17 (3), pp. e1009254 - ? | |
dc.identifier.issn | 1553-7390 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4421 | |
dc.identifier.eissn | 1553-7404 | |
dc.identifier.doi | 10.1371/journal.pgen.1009254 | |
dc.description.abstract | Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes rel to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites. | |
dc.format | Print-Electronic | |
dc.format.extent | e1009254 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | PUBLIC LIBRARY SCIENCE | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-11-05 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1371/journal.pgen.1009254 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-03-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | PLoS genetics | |
pubs.issue | 3 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 17 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Houlston, Richard | |