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dc.contributor.authorLesseur, C
dc.contributor.authorFerreiro-Iglesias, A
dc.contributor.authorMcKay, JD
dc.contributor.authorBossé, Y
dc.contributor.authorJohansson, M
dc.contributor.authorGaborieau, V
dc.contributor.authorLandi, MT
dc.contributor.authorChristiani, DC
dc.contributor.authorCaporaso, NC
dc.contributor.authorBojesen, SE
dc.contributor.authorAmos, CI
dc.contributor.authorShete, S
dc.contributor.authorLiu, G
dc.contributor.authorRennert, G
dc.contributor.authorAlbanes, D
dc.contributor.authorAldrich, MC
dc.contributor.authorTardon, A
dc.contributor.authorChen, C
dc.contributor.authorTriantafillos, L
dc.contributor.authorField, JK
dc.contributor.authorTeare, MD
dc.contributor.authorKiemeney, LA
dc.contributor.authorDiergaarde, B
dc.contributor.authorFerris, RL
dc.contributor.authorZienolddiny, S
dc.contributor.authorLam, S
dc.contributor.authorOlshan, AF
dc.contributor.authorWeissler, MC
dc.contributor.authorLacko, M
dc.contributor.authorRisch, A
dc.contributor.authorBickeböller, H
dc.contributor.authorNess, AR
dc.contributor.authorThomas, S
dc.contributor.authorLe Marchand, L
dc.contributor.authorSchabath, MB
dc.contributor.authorWünsch-Filho, V
dc.contributor.authorTajara, EH
dc.contributor.authorAndrew, AS
dc.contributor.authorClifford, GM
dc.contributor.authorLazarus, P
dc.contributor.authorGrankvist, K
dc.contributor.authorJohansson, M
dc.contributor.authorArnold, S
dc.contributor.authorMelander, O
dc.contributor.authorBrunnström, H
dc.contributor.authorBoccia, S
dc.contributor.authorCadoni, G
dc.contributor.authorTimens, W
dc.contributor.authorObeidat, M
dc.contributor.authorXiao, X
dc.contributor.authorHoulston, RS
dc.contributor.authorHung, RJ
dc.contributor.authorBrennan, P
dc.date.accessioned2021-03-22T10:15:21Z
dc.date.available2021-03-22T10:15:21Z
dc.date.issued2021-03-05
dc.identifier.citationPLoS genetics, 2021, 17 (3), pp. e1009254 - ?
dc.identifier.issn1553-7390
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4421
dc.identifier.eissn1553-7404
dc.identifier.doi10.1371/journal.pgen.1009254
dc.description.abstractSquamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes rel to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.
dc.formatPrint-Electronic
dc.format.extente1009254 - ?
dc.languageeng
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.
dc.typeJournal Article
dcterms.dateAccepted2020-11-05
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1371/journal.pgen.1009254
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-03-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPLoS genetics
pubs.issue3
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNo embargo
icr.researchteamCancer Genomics
icr.researchteamCancer Genomics
dc.contributor.icrauthorHoulston, Richard


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