Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper.
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Date
2020-09-15ICR Author
Author
Gomes, F
Wong, M
Battisti, NML
Kordbacheh, T
Kiderlen, M
Greystoke, A
Luciani, A
Type
Journal Article
Metadata
Show full item recordAbstract
Immunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.
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Subject
Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Antineoplastic Agents
Immunotherapy
Radioimmunotherapy
Clinical Trials as Topic
Immunosenescence
Immune Checkpoint Inhibitors
Research team
Breast Cancer Clinical Research
Breast Cancer Clinical Research
Language
eng
Date accepted
2020-06-23
Citation
British journal of cancer, 2020, 123 (6), pp. 874 - 884
Publisher
SPRINGERNATURE