dc.contributor.author | Barwick, T | |
dc.contributor.author | Orton, M | |
dc.contributor.author | Koh, DM | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Rockall, A | |
dc.contributor.author | Tunariu, N | |
dc.contributor.author | Blackledge, M | |
dc.contributor.author | Messiou, C | |
dc.date.accessioned | 2021-03-31T09:55:39Z | |
dc.date.available | 2021-03-31T09:55:39Z | |
dc.date.issued | 2021-04-01 | |
dc.identifier.citation | The British journal of radiology, 2021, 94 (1120), pp. 20200682 - ? | |
dc.identifier.issn | 0007-1285 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4471 | |
dc.identifier.eissn | 1748-880X | |
dc.identifier.doi | 10.1259/bjr.20200682 | |
dc.description.abstract | OBJECTIVE: To assess intra- and inter-reader variability of apparent diffusion coefficient (ADC) and fat fraction (FF) measurement in focal myeloma bone lesions and the influence of lesion size. METHODS: 22 myeloma patients with focal active disease on whole body MRI were included. Two readers outlined a small (5-10 mm) and large lesion (>10 mm) in each subject on derived ADC and FF maps; one reader performed this twice. Intra- and inter-reader agreement for small and large lesion groups were calculated for derived statistics from each map using within-subject standard deviation, coefficient of variation, interclass correlation coefficient measures, and visualized with Bland-Altman plots. RESULTS: For mean ADC, intra- and inter-reader repeatability demonstrated equivalently low coefficient of variation (3.0-3.6%) and excellent interclass correlation coefficient (0.975-0.982) for both small and large lesions. For mean FF, intra- and inter-reader repeatability was significantly poorer for small lesions compared to large lesions (intra-reader within-subject standard variation estimate is 2.7 times higher for small lesions than large lesions (p = 0.0071), and for inter-reader variations is 3.8 times higher (p = 0.0070)). CONCLUSION: There is excellent intra- and inter-reader agreement for mean ADC estimates, even for lesions as small as 5 mm. For FF measurements, there is a significant increase in coefficient of variation for smaller lesions, suggesting lesions >10 mm should be selected for lesion FF measurement. ADVANCES IN KNOWLEDGE: ADC measurements of focal myeloma have excellent intra- and inter-reader agreement. FF measurements are more susceptible to lesion size as intra- and inter-reader agreement is significantly impaired in lesions less than 10 mm. | |
dc.format | Print-Electronic | |
dc.format.extent | 20200682 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BRITISH INST RADIOLOGY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Repeatability and reproducibility of apparent diffusion coefficient and fat fraction measurement of focal myeloma lesions on whole body magnetic resonance imaging. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-01-07 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1259/bjr.20200682 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | The British journal of radiology | |
pubs.issue | 1120 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.publication-status | Accepted | |
pubs.volume | 94 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Myeloma Group | |
icr.researchteam | Myeloma Group | |
dc.contributor.icrauthor | Kaiser, Martin | |
dc.contributor.icrauthor | Blackledge, Matthew | |