The delineation of intraprostatic boost regions for radiotherapy using multimodality imaging.
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Date
2016-11-01ICR Author
Author
Pathmanathan, AU
Alexander, EJ
Huddart, RA
Tree, AC
Type
Journal Article
Metadata
Show full item recordAbstract
Dose escalation to the prostate improves tumor control but at the expense of increased rectal toxicity. Modern imaging can be used to detect the most common site of recurrence, the intraprostatic lesion (IPL), which has led to the concept of focusing dose escalation to the IPL in order to improve the therapeutic ratio. Imaging must be able to detect lesions with adequate sensitivity and specificity to accurately delineate the IPL. This information must be carefully integrated into the radiotherapy planning process to ensure the dose is targeted to the IPL. This review will consider the role and challenges of multiparametric MRI and PET computed tomography in delineating a tumor boost to be delivered by external beam radiotherapy.
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Subject
Humans
Prostatic Neoplasms
Magnetic Resonance Imaging
Neoplasm Staging
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Reproducibility of Results
Male
Multimodal Imaging
Positron Emission Tomography Computed Tomography
Research team
Clinical Academic Radiotherapy (Huddart)
Language
eng
Date accepted
2016-05-01
License start date
2016-11
Citation
Future oncology (London, England), 2016, 12 (21), pp. 2495 - 2511
Publisher
FUTURE MEDICINE LTD