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dc.contributor.authorGerlinger, M
dc.date.accessioned2021-04-12T08:47:34Z
dc.date.available2021-04-12T08:47:34Z
dc.identifier.citationCancer cell, 2021, 39 (1), pp. 16 - 18
dc.identifier.issn1535-6108
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4515
dc.identifier.eissn1878-3686
dc.identifier.doi10.1016/j.ccell.2020.12.016
dc.description.abstractAbundant neoantigens are considered responsible for the immunotherapy sensitivity of mismatch repair-deficient (MMRd) cancers. In this issue of Cancer Cell, two papers show that MLH1 mismatch repair gene loss promotes cGAS-STING activation, interferon secretion, and T cell priming. This may be essential for the high immunotherapy sensitivity in MMRd cancer.
dc.formatPrint
dc.format.extent16 - 18
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.titleImmunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough.
dc.typeJournal Article
dcterms.dateAccepted2020-12-07
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.ccell.2020.12.016
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer cell
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics
pubs.publication-statusPublished
pubs.volume39
pubs.embargo.termsNot known
icr.researchteamTranslational Oncogenomics
icr.researchteamTranslational Oncogenomicsen_US
dc.contributor.icrauthorGerlinger, Marcoen


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