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Immunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough.

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ICR Author
Gerlinger, Marco
Author
Gerlinger, M
Type
Journal Article
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Abstract
Abundant neoantigens are considered responsible for the immunotherapy sensitivity of mismatch repair-deficient (MMRd) cancers. In this issue of Cancer Cell, two papers show that MLH1 mismatch repair gene loss promotes cGAS-STING activation, interferon secretion, and T cell priming. This may be essential for the high immunotherapy sensitivity in MMRd cancer.
URI
https://repository.icr.ac.uk/handle/internal/4515
DOI
https://doi.org/10.1016/j.ccell.2020.12.016
Collections
  • Molecular Pathology
Research team
Translational Oncogenomics
Translational Oncogenomics
Language
eng
Date accepted
2020-12-07
Citation
Cancer cell, 2021, 39 (1), pp. 16 - 18

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