Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study.
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<h4>Background</h4>This study examined sociodemographic factors, cisplatin-related adverse health outcomes (AHO), and cumulative burden of morbidity (CBM<sub>Pt</sub>) scores associated with medication use for anxiety and/or depression in testicular cancer survivors (TCS).<h4>Methods</h4>A total of 1,802 TCS who completed cisplatin-based chemotherapy ≥12 months previously completed questionnaires regarding sociodemographic features and cisplatin-related AHOs [hearing impairment, tinnitus, peripheral sensory neuropathy (PSN), and kidney disease]. A CBM<sub>Pt</sub> score encompassed the number and severity of cisplatin-related AHOs. Multivariable logistic regression models assessed the relationship of individual AHOs and CBM<sub>Pt</sub> with medication use for anxiety and/or depression.<h4>Results</h4>A total of 151 TCS (8.4%) used medications for anxiety and/or depression. No cisplatin-related AHOs were reported by 511 (28.4%) participants, whereas 622 (34.5%), 334 (18.5%), 287 (15.9%), and 48 (2.7%), respectively, had very low, low, medium, and high CBM<sub>Pt</sub> scores. In the multivariable model, higher CBM<sub>Pt</sub> scores were significantly associated with medication use for anxiety and/or depression (<i>P</i> < 0.0001). In addition, tinnitus (<i>P</i> = 0.0009), PSN (<i>P</i> = 0.02), and having health insurance (<i>P</i> = 0.05) were significantly associated with greater use of these medications, whereas being employed (<i>P</i> = 0.0005) and vigorous physical activity (<i>P</i> = 0.01) were significantly associated with diminished use.<h4>Conclusions</h4>TCS with higher CBM<sub>Pt</sub> scores had a higher probability of using medications for anxiety and/or depression, and conversely, those who were employed and physically active tended to have reduced use of these medications.<h4>Impact</h4>Healthcare providers should encourage TCS to increase physical activity to improve both physical and mental health. Rehabilitation programs should assess work-related skills and provide career development counseling/training.
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Clinical Academic Radiotherapy (Huddart)
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021, 30 (6), pp. 1129 - 1138