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dc.contributor.authorBiganzoli, L
dc.contributor.authorBattisti, NML
dc.contributor.authorWildiers, H
dc.contributor.authorMcCartney, A
dc.contributor.authorColloca, G
dc.contributor.authorKunkler, IH
dc.contributor.authorCardoso, M-J
dc.contributor.authorCheung, K-L
dc.contributor.authorde Glas, NA
dc.contributor.authorTrimboli, RM
dc.contributor.authorKorc-Grodzicki, B
dc.contributor.authorSoto-Perez-de-Celis, E
dc.contributor.authorPonti, A
dc.contributor.authorTsang, J
dc.contributor.authorMarotti, L
dc.contributor.authorBenn, K
dc.contributor.authorAapro, MS
dc.contributor.authorBrain, EGC
dc.date.accessioned2021-08-11T13:47:02Z
dc.date.available2021-08-11T13:47:02Z
dc.identifier.citationThe Lancet. Oncology, 2021, 22 (7), pp. e327 - e340
dc.identifier.issn1470-2045
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4736
dc.identifier.eissn1474-5488
dc.identifier.eissn1474-5488en_US
dc.identifier.doi10.1016/s1470-2045(20)30741-5
dc.identifier.doi10.1016/s1470-2045(20)30741-5en_US
dc.description.abstractBreast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficient evidence specific to older adults. Decision making should not be driven by age alone but should involve geriatric assessments plus careful consideration of life expectancy, competing risks of mortality, and patient preferences. A multidisciplinary taskforce, including members of the European Society of Breast Cancer Specialists and International Society of Geriatric Oncology, gathered to expand and update the previous 2012 evidence-based recommendations for the management of breast cancer in older individuals with the endorsement of the European Cancer Organisation. These guidelines were expanded to include chemotherapy toxicity prediction calculators, cultural and social considerations, surveillance imaging, genetic screening, gene expression profiles, neoadjuvant systemic treatment options, bone-modifying drugs, targeted therapies, and supportive care. Recommendations on geriatric assessment, ductal carcinoma in situ, screening, primary endocrine therapy, surgery, radiotherapy, adjuvant systemic therapy, and secondary breast cancer were updated.
dc.formatPrint-Electronic
dc.format.extente327 - e340
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectPrognosis
dc.subjectGeriatric Assessment
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectPredictive Value of Tests
dc.subjectConsensus
dc.subjectMedical Oncology
dc.subjectAge Factors
dc.subjectDecision Support Techniques
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFemale
dc.subjectClinical Decision-Making
dc.titleUpdated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
dc.typeJournal Article
dcterms.dateAccepted2020-12-02
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/s1470-2045(20)30741-5
dc.relation.isPartOfThe Lancet. Oncology
pubs.issue7
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Breast Cancer Clinical Research
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Breast Cancer Clinical Research
pubs.publication-statusPublished
pubs.volume22en_US
pubs.embargo.termsNo embargo
icr.researchteamBreast Cancer Clinical Research
icr.researchteamBreast Cancer Clinical Researchen_US
dc.contributor.icrauthorBattisti, Nicoloen


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