Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
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Date
2021-07-01ICR Author
Author
Biganzoli, L
Battisti, NML
Wildiers, H
McCartney, A
Colloca, G
Kunkler, IH
Cardoso, M-J
Cheung, K-L
de Glas, NA
Trimboli, RM
Korc-Grodzicki, B
Soto-Perez-de-Celis, E
Ponti, A
Tsang, J
Marotti, L
Benn, K
Aapro, MS
Brain, EGC
Type
Journal Article
Metadata
Show full item recordAbstract
Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficient evidence specific to older adults. Decision making should not be driven by age alone but should involve geriatric assessments plus careful consideration of life expectancy, competing risks of mortality, and patient preferences. A multidisciplinary taskforce, including members of the European Society of Breast Cancer Specialists and International Society of Geriatric Oncology, gathered to expand and update the previous 2012 evidence-based recommendations for the management of breast cancer in older individuals with the endorsement of the European Cancer Organisation. These guidelines were expanded to include chemotherapy toxicity prediction calculators, cultural and social considerations, surveillance imaging, genetic screening, gene expression profiles, neoadjuvant systemic treatment options, bone-modifying drugs, targeted therapies, and supportive care. Recommendations on geriatric assessment, ductal carcinoma in situ, screening, primary endocrine therapy, surgery, radiotherapy, adjuvant systemic therapy, and secondary breast cancer were updated.
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Subject
Humans
Breast Neoplasms
Prognosis
Geriatric Assessment
Risk Assessment
Risk Factors
Predictive Value of Tests
Consensus
Medical Oncology
Age Factors
Decision Support Techniques
Aged
Aged, 80 and over
Female
Clinical Decision-Making
Research team
Breast Cancer Clinical Research
Breast Cancer Clinical Research
Language
eng
Date accepted
2020-12-02
Citation
The Lancet. Oncology, 2021, 22 (7), pp. e327 - e340
Publisher
ELSEVIER SCIENCE INC