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dc.contributor.authorPark, HA
dc.contributor.authorNeumeyer, S
dc.contributor.authorMichailidou, K
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorDennis, J
dc.contributor.authorAhearn, TU
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorAugustinsson, A
dc.contributor.authorBaten, A
dc.contributor.authorBeane Freeman, LE
dc.contributor.authorBecher, H
dc.contributor.authorBeckmann, MW
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrucker, SY
dc.contributor.authorBurwinkel, B
dc.contributor.authorCampa, D
dc.contributor.authorCanzian, F
dc.contributor.authorCastelao, JE
dc.contributor.authorChanock, SJ
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorClarke, CL
dc.contributor.authorNBCS Collaborators
dc.contributor.authorConroy, DM
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorDevilee, P
dc.contributor.authorDörk, T
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorDwek, M
dc.contributor.authorEccles, DM
dc.contributor.authorEliassen, AH
dc.contributor.authorEngel, C
dc.contributor.authorEriksson, M
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFlyger, H
dc.contributor.authorFritschi, L
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGarcía-Sáenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGoldberg, MS
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGrip, M
dc.contributor.authorGuénel, P
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHan, S
dc.contributor.authorHarkness, EF
dc.contributor.authorHart, SN
dc.contributor.authorHe, W
dc.contributor.authorHeemskerk-Gerritsen, BAM
dc.contributor.authorHopper, JL
dc.contributor.authorHunter, DJ
dc.contributor.authorABCTB Investigators
dc.contributor.authorkConFab Investigators
dc.contributor.authorJager, A
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorJung, A
dc.contributor.authorKaaks, R
dc.contributor.authorKapoor, PM
dc.contributor.authorKeeman, R
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKitahara, CM
dc.contributor.authorKoppert, LB
dc.contributor.authorKoutros, S
dc.contributor.authorKristensen, VN
dc.contributor.authorKurian, AW
dc.contributor.authorLacey, J
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLo, W-Y
dc.contributor.authorLubiński, J
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMavroudis, D
dc.contributor.authorMeindl, A
dc.contributor.authorMenon, U
dc.contributor.authorMilne, RL
dc.contributor.authorMuranen, TA
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewman, WG
dc.contributor.authorNordestgaard, BG
dc.contributor.authorOffit, K
dc.contributor.authorOlshan, AF
dc.contributor.authorOlsson, H
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPeterlongo, P
dc.contributor.authorPeto, J
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPresneau, N
dc.contributor.authorRadice, P
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorRomero, A
dc.contributor.authorSaloustros, E
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmidt, MK
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSchwentner, L
dc.contributor.authorScott, C
dc.contributor.authorShah, M
dc.contributor.authorShu, X-O
dc.contributor.authorSimard, J
dc.contributor.authorSmeets, A
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorStevens, V
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTamimi, RM
dc.contributor.authorTapper, WJ
dc.contributor.authorTaylor, JA
dc.contributor.authorTerry, MB
dc.contributor.authorTomlinson, I
dc.contributor.authorTroester, MA
dc.contributor.authorTruong, T
dc.contributor.authorVachon, CM
dc.contributor.authorvan Veen, EM
dc.contributor.authorVijai, J
dc.contributor.authorWang, S
dc.contributor.authorWendt, C
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorZiogas, A
dc.contributor.authorDunning, AM
dc.contributor.authorPharoah, PDP
dc.contributor.authorEaston, DF
dc.contributor.authorZheng, W
dc.contributor.authorKraft, P
dc.contributor.authorChang-Claude, J
dc.date.accessioned2021-10-20T10:16:20Z
dc.date.available2021-10-20T10:16:20Z
dc.identifier.citationBritish journal of cancer, 2021, 125 (8), pp. 1135 - 1145
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4839
dc.identifier.eissn1532-1827
dc.identifier.doi10.1038/s41416-021-01432-8
dc.description.abstractBackground Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10 -2 ), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
dc.formatPrint-Electronic
dc.format.extent1135 - 1145
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectNBCS Collaborators
dc.subjectABCTB Investigators
dc.subjectkConFab Investigators
dc.titleMendelian randomisation study of smoking exposure in relation to breast cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2021-04-28
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41416-021-01432-8
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBritish journal of cancer
pubs.issue8
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume125
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
dc.contributor.icrauthorSchoemaker, Minouken


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