Recent Advances in ALK2 Inhibitors.
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Date
2021-08-17ICR Author
Author
Rooney, L
Jones, C
Type
Journal Article
Metadata
Show full item recordAbstract
Activin receptor-like kinase-2 (ALK2) is a type I bone morphogenetic protein (BMP) receptor which has a role in biological processes that control the development of bone, heart, brain, and other tissue. Gain of function mutations in ALK2 have been identified in fibrodysplasia ossificans progressiva (FOP) and the childhood brain tumor, diffuse intrinsic pontine glioma (DIPG), which has given focus to the development of ALK2 inhibitors as targeted treatments. This review covers the structural features of ALK2 inhibitors which contribute to their ALK2 potency and selectivity, and the pharmacokinetic or in vivo efficacy data available to demonstrate their suitability for treating a peripheral or CNS disease.
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Research team
Glioma Team
Language
eng
Date accepted
2021-07-26
License start date
2021-08-06
Citation
ACS omega, 2021, 6 (32), pp. 20729 - 20734
Publisher
AMER CHEMICAL SOC