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dc.contributor.authorAuvinen, A
dc.contributor.authorCardis, E
dc.contributor.authorBlettner, M
dc.contributor.authorMoissonnier, M
dc.contributor.authorSadetzki, S
dc.contributor.authorGiles, G
dc.contributor.authorJohansen, C
dc.contributor.authorSwerdlow, A
dc.contributor.authorCook, A
dc.contributor.authorFleming, S
dc.contributor.authorBerg-Beckhoff, G
dc.contributor.authorIavarone, I
dc.contributor.authorParent, M-E
dc.contributor.authorWoodward, A
dc.contributor.authorTynes, T
dc.contributor.authorMcBride, M
dc.contributor.authorKrewski, D
dc.contributor.authorFeyching, M
dc.contributor.authorTakebayashi, T
dc.contributor.authorArmstrong, B
dc.contributor.authorHours, M
dc.contributor.authorSiemiatycki, J
dc.contributor.authorLagorio, S
dc.contributor.authorLarsen, SB
dc.contributor.authorSchoemaker, M
dc.contributor.authorKlaeboe, L
dc.contributor.authorLönn, S
dc.contributor.authorSchüz, J
dc.contributor.authorand the INTERPHONE study group
dc.date.accessioned2022-01-07T09:53:12Z
dc.date.available2022-01-07T09:53:12Z
dc.date.issued2021-10-14
dc.identifier.citationInternational journal of epidemiology, 2021
dc.identifier.issn0300-5771
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4945
dc.identifier.eissn1464-3685
dc.identifier.doi10.1093/ije/dyab140
dc.description.abstractBackground Exposure to high doses of ionizing radiation is among the few well-established brain tumour risk factors. We used data from the Interphone study to evaluate the effects of exposure to low-dose radiation from diagnostic radiological examinations on glioma, meningioma and acoustic neuroma risk. Methods Brain tumour cases (2644 gliomas, 2236 meningiomas, 1083 neuromas) diagnosed in 2000-02 were identified through hospitals in 13 countries, and 6068 controls (population-based controls in most centres) were included in the analysis. Participation across all centres was 64% for glioma cases, 78% for meningioma cases, 82% for acoustic neuroma cases and 53% for controls. Information on previous diagnostic radiological examinations was obtained by interviews, including the frequency, timing and indication for the examinations. Typical brain doses per type of examination were estimated based on the literature. Examinations within the 5 years before the index date were excluded from the dose estimation. Adjusted odds ratios were estimated using conditional logistic regression. Results No materially or consistently increased odds ratios for glioma, meningioma or acoustic neuroma were found for any specific type of examination, including computed tomography of the head and cerebral angiography. The only indication of an elevated risk was an increasing trend in risk of meningioma with the number of isotope scans, but no such trends for other examinations were observed. No gradient was found in risk with estimated brain dose. Age at exposure did not substantially modify the findings. Sensitivity analyses gave results consistent with the main analysis. Conclusions There was no consistent evidence for increased risks of brain tumours with X-ray examinations, although error from selection and recall bias cannot be completely excluded. A cautious interpretation is warranted for the observed association between isotope scans and meningioma.
dc.formatPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectand the INTERPHONE study group
dc.titleDiagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study.
dc.typeJournal Article
dcterms.dateAccepted2021-10-14
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1093/ije/dyab140
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-10-14
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of epidemiology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
dc.contributor.icrauthorSchoemaker, Minouken_US


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