dc.contributor.author | Fendler, A | |
dc.contributor.author | Shepherd, STC | |
dc.contributor.author | Au, L | |
dc.contributor.author | Wilkinson, KA | |
dc.contributor.author | Wu, M | |
dc.contributor.author | Byrne, F | |
dc.contributor.author | Cerrone, M | |
dc.contributor.author | Schmitt, AM | |
dc.contributor.author | Joharatnam-Hogan, N | |
dc.contributor.author | Shum, B | |
dc.contributor.author | Tippu, Z | |
dc.contributor.author | Rzeniewicz, K | |
dc.contributor.author | Boos, LA | |
dc.contributor.author | Harvey, R | |
dc.contributor.author | Carlyle, E | |
dc.contributor.author | Edmonds, K | |
dc.contributor.author | Del Rosario, L | |
dc.contributor.author | Sarker, S | |
dc.contributor.author | Lingard, K | |
dc.contributor.author | Mangwende, M | |
dc.contributor.author | Holt, L | |
dc.contributor.author | Ahmod, H | |
dc.contributor.author | Korteweg, J | |
dc.contributor.author | Foley, T | |
dc.contributor.author | Bazin, J | |
dc.contributor.author | Gordon, W | |
dc.contributor.author | Barber, T | |
dc.contributor.author | Emslie-Henry, A | |
dc.contributor.author | Xie, W | |
dc.contributor.author | Gerard, CL | |
dc.contributor.author | Deng, D | |
dc.contributor.author | Wall, EC | |
dc.contributor.author | Agua-Doce, A | |
dc.contributor.author | Namjou, S | |
dc.contributor.author | Caidan, S | |
dc.contributor.author | Gavrielides, M | |
dc.contributor.author | MacRae, JI | |
dc.contributor.author | Kelly, G | |
dc.contributor.author | Peat, K | |
dc.contributor.author | Kelly, D | |
dc.contributor.author | Murra, A | |
dc.contributor.author | Kelly, K | |
dc.contributor.author | O'Flaherty, M | |
dc.contributor.author | Dowdie, L | |
dc.contributor.author | Ash, N | |
dc.contributor.author | Gronthoud, F | |
dc.contributor.author | Shea, RL | |
dc.contributor.author | Gardner, G | |
dc.contributor.author | Murray, D | |
dc.contributor.author | Kinnaird, F | |
dc.contributor.author | Cui, W | |
dc.contributor.author | Pascual, J | |
dc.contributor.author | Rodney, S | |
dc.contributor.author | Mencel, J | |
dc.contributor.author | Curtis, O | |
dc.contributor.author | Stephenson, C | |
dc.contributor.author | Robinson, A | |
dc.contributor.author | Oza, B | |
dc.contributor.author | Farag, S | |
dc.contributor.author | Leslie, I | |
dc.contributor.author | Rogiers, A | |
dc.contributor.author | Iyengar, S | |
dc.contributor.author | Ethell, M | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Cunningham, D | |
dc.contributor.author | Chau, I | |
dc.contributor.author | Starling, N | |
dc.contributor.author | Turner, N | |
dc.contributor.author | Welsh, L | |
dc.contributor.author | van As, N | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Droney, J | |
dc.contributor.author | Banerjee, S | |
dc.contributor.author | Tatham, KC | |
dc.contributor.author | O'Brien, M | |
dc.contributor.author | Harrington, K | |
dc.contributor.author | Bhide, S | |
dc.contributor.author | Okines, A | |
dc.contributor.author | Reid, A | |
dc.contributor.author | Young, K | |
dc.contributor.author | Furness, AJS | |
dc.contributor.author | Pickering, L | |
dc.contributor.author | Swanton, C | |
dc.contributor.author | Crick COVID-19 Consortium, | |
dc.contributor.author | Gandhi, S | |
dc.contributor.author | Gamblin, S | |
dc.contributor.author | Bauer, DLV | |
dc.contributor.author | Kassiotis, G | |
dc.contributor.author | Kumar, S | |
dc.contributor.author | Yousaf, N | |
dc.contributor.author | Jhanji, S | |
dc.contributor.author | Nicholson, E | |
dc.contributor.author | Howell, M | |
dc.contributor.author | Walker, S | |
dc.contributor.author | Wilkinson, RJ | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Turajlic, S | |
dc.contributor.author | CAPTURE Consortium, | |
dc.date.accessioned | 2022-02-18T10:30:02Z | |
dc.date.available | 2022-02-18T10:30:02Z | |
dc.date.issued | 2021-10-27 | |
dc.identifier.citation | Nature cancer, 2021, 2 (12), pp. 1305 - 1320 | |
dc.identifier.issn | 2662-1347 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5013 | |
dc.identifier.eissn | 2662-1347 | |
dc.identifier.eissn | 2662-1347 | |
dc.identifier.doi | 10.1038/s43018-021-00274-w | |
dc.identifier.doi | 10.1038/s43018-021-00274-w | |
dc.description.abstract | Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic. | |
dc.format | Print-Electronic | |
dc.format.extent | 1305 - 1320 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Crick COVID-19 Consortium | |
dc.subject | CAPTURE Consortium | |
dc.title | Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-09-17 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s43018-021-00274-w | |
dc.relation.isPartOf | Nature cancer | |
pubs.issue | 12 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/MD(Res) | |
pubs.organisational-group | /ICR/Students/MD(Res)/Starting Cohort 20/21 | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular Oncology | |
icr.researchteam | Medicine (RMH Smith Cunningham) | |
icr.researchteam | Melanoma and Kidney Cancer | |
dc.contributor.icrauthor | Shepherd, Scott | |
dc.contributor.icrauthor | Au, Lewis | |
dc.contributor.icrauthor | Shum, Ben | |
dc.contributor.icrauthor | Pascual, Javier | |
dc.contributor.icrauthor | Curtis, Olivia | |
dc.contributor.icrauthor | Turner, Nicholas | |
dc.contributor.icrauthor | Harrington, Kevin | |
dc.contributor.icrauthor | Bhide, Shreerang | |
dc.contributor.icrauthor | Furness, Andrew | |