Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study.
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Date
2021-10-27ICR Author
Author
Fendler, A
Shepherd, STC
Au, L
Wilkinson, KA
Wu, M
Byrne, F
Cerrone, M
Schmitt, AM
Joharatnam-Hogan, N
Shum, B
Tippu, Z
Rzeniewicz, K
Boos, LA
Harvey, R
Carlyle, E
Edmonds, K
Del Rosario, L
Sarker, S
Lingard, K
Mangwende, M
Holt, L
Ahmod, H
Korteweg, J
Foley, T
Bazin, J
Gordon, W
Barber, T
Emslie-Henry, A
Xie, W
Gerard, CL
Deng, D
Wall, EC
Agua-Doce, A
Namjou, S
Caidan, S
Gavrielides, M
MacRae, JI
Kelly, G
Peat, K
Kelly, D
Murra, A
Kelly, K
O'Flaherty, M
Dowdie, L
Ash, N
Gronthoud, F
Shea, RL
Gardner, G
Murray, D
Kinnaird, F
Cui, W
Pascual, J
Rodney, S
Mencel, J
Curtis, O
Stephenson, C
Robinson, A
Oza, B
Farag, S
Leslie, I
Rogiers, A
Iyengar, S
Ethell, M
Messiou, C
Cunningham, D
Chau, I
Starling, N
Turner, N
Welsh, L
van As, N
Jones, RL
Droney, J
Banerjee, S
Tatham, KC
O'Brien, M
Harrington, K
Bhide, S
Okines, A
Reid, A
Young, K
Furness, AJS
Pickering, L
Swanton, C
Crick COVID-19 Consortium,
Gandhi, S
Gamblin, S
Bauer, DLV
Kassiotis, G
Kumar, S
Yousaf, N
Jhanji, S
Nicholson, E
Howell, M
Walker, S
Wilkinson, RJ
Larkin, J
Turajlic, S
CAPTURE Consortium,
Type
Journal Article
Metadata
Show full item recordAbstract
Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic.
Collections
Subject
Crick COVID-19 Consortium
CAPTURE Consortium
Research team
Molecular Oncology
Medicine (RMH Smith Cunningham)
Melanoma and Kidney Cancer
Language
eng
Date accepted
2021-09-17
Citation
Nature cancer, 2021, 2 (12), pp. 1305 - 1320
Publisher
NATURE PORTFOLIO