dc.contributor.author | Fu, X | |
dc.contributor.author | Zhao, Y | |
dc.contributor.author | Lopez, JI | |
dc.contributor.author | Rowan, A | |
dc.contributor.author | Au, L | |
dc.contributor.author | Fendler, A | |
dc.contributor.author | Hazell, S | |
dc.contributor.author | Xu, H | |
dc.contributor.author | Horswell, S | |
dc.contributor.author | Shepherd, STC | |
dc.contributor.author | Spencer, CE | |
dc.contributor.author | Spain, L | |
dc.contributor.author | Byrne, F | |
dc.contributor.author | Stamp, G | |
dc.contributor.author | O'Brien, T | |
dc.contributor.author | Nicol, D | |
dc.contributor.author | Augustine, M | |
dc.contributor.author | Chandra, A | |
dc.contributor.author | Rudman, S | |
dc.contributor.author | Toncheva, A | |
dc.contributor.author | Furness, AJS | |
dc.contributor.author | Pickering, L | |
dc.contributor.author | Kumar, S | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Dafydd, DA | |
dc.contributor.author | Orton, MR | |
dc.contributor.author | Doran, SJ | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Swanton, C | |
dc.contributor.author | Sahai, E | |
dc.contributor.author | Litchfield, K | |
dc.contributor.author | Turajlic, S | |
dc.contributor.author | TRACERx Renal Consortium, | |
dc.contributor.author | Bates, PA | |
dc.date.accessioned | 2022-03-22T09:15:12Z | |
dc.date.available | 2022-03-22T09:15:12Z | |
dc.date.issued | 2022-01-01 | |
dc.identifier.citation | Nature ecology & evolution, 2022, 6 (1), pp. 88 - 102 | |
dc.identifier.issn | 2397-334X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5041 | |
dc.identifier.eissn | 2397-334X | |
dc.identifier.eissn | 2397-334X | |
dc.identifier.doi | 10.1038/s41559-021-01586-x | |
dc.identifier.doi | 10.1038/s41559-021-01586-x | |
dc.description.abstract | Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification in clear cell renal cell carcinoma through a combination of modelling and real tumour analysis. We observe that the mode of tumour growth, surface or volume, impacts the extent of subclonal diversification, enabling interpretation of clonal diversity in patient tumours. Specific patterns of proliferation and necrosis explain clonal expansion and emergence of parallel evolution and microdiversity in tumours. In silico time-course studies reveal the appearance of budding structures before detectable subclonal diversification. Intriguingly, we observe radiological evidence of budding structures in early-stage clear cell renal cell carcinoma, indicating that future clonal evolution may be predictable from imaging. Our findings offer a window into the temporal and spatial features of clinically relevant clonal evolution. | |
dc.format | Print-Electronic | |
dc.format.extent | 88 - 102 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | TRACERx Renal Consortium | |
dc.title | Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-10-07 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41559-021-01586-x | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.relation.isPartOf | Nature ecology & evolution | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Melanoma and Kidney Cancer | |
icr.researchteam | Experimental Pathology | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | Au, Lewis | |
dc.contributor.icrauthor | Shepherd, Scott | |
dc.contributor.icrauthor | Furness, Andrew | |
dc.contributor.icrauthor | Doran, Simon | |