Show simple item record

dc.contributor.authorDareng, EO
dc.contributor.authorTyrer, JP
dc.contributor.authorBarnes, DR
dc.contributor.authorJones, MR
dc.contributor.authorYang, X
dc.contributor.authorAben, KKH
dc.contributor.authorAdank, MA
dc.contributor.authorAgata, S
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorAravantinos, G
dc.contributor.authorArun, BK
dc.contributor.authorAugustinsson, A
dc.contributor.authorBalmaña, J
dc.contributor.authorBandera, EV
dc.contributor.authorBarkardottir, RB
dc.contributor.authorBarrowdale, D
dc.contributor.authorBeckmann, MW
dc.contributor.authorBeeghly-Fadiel, A
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBernardini, MQ
dc.contributor.authorBjorge, L
dc.contributor.authorBlack, A
dc.contributor.authorBogdanova, NV
dc.contributor.authorBonanni, B
dc.contributor.authorBorg, A
dc.contributor.authorBrenton, JD
dc.contributor.authorBudzilowska, A
dc.contributor.authorButzow, R
dc.contributor.authorBuys, SS
dc.contributor.authorCai, H
dc.contributor.authorCaligo, MA
dc.contributor.authorCampbell, I
dc.contributor.authorCannioto, R
dc.contributor.authorCassingham, H
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChen, K
dc.contributor.authorChiew, Y-E
dc.contributor.authorChung, WK
dc.contributor.authorClaes, KBM
dc.contributor.authorColonna, S
dc.contributor.authorGEMO Study Collaborators,
dc.contributor.authorGC-HBOC Study Collaborators,
dc.contributor.authorEMBRACE Collaborators,
dc.contributor.authorCook, LS
dc.contributor.authorCouch, FJ
dc.contributor.authorDaly, MB
dc.contributor.authorDao, F
dc.contributor.authorDavies, E
dc.contributor.authorde la Hoya, M
dc.contributor.authorde Putter, R
dc.contributor.authorDennis, J
dc.contributor.authorDePersia, A
dc.contributor.authorDevilee, P
dc.contributor.authorDiez, O
dc.contributor.authorDing, YC
dc.contributor.authorDoherty, JA
dc.contributor.authorDomchek, SM
dc.contributor.authorDörk, T
dc.contributor.authordu Bois, A
dc.contributor.authorDürst, M
dc.contributor.authorEccles, DM
dc.contributor.authorEliassen, HA
dc.contributor.authorEngel, C
dc.contributor.authorEvans, GD
dc.contributor.authorFasching, PA
dc.contributor.authorFlanagan, JM
dc.contributor.authorFortner, RT
dc.contributor.authorMachackova, E
dc.contributor.authorFriedman, E
dc.contributor.authorGanz, PA
dc.contributor.authorGarber, J
dc.contributor.authorGensini, F
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGoodman, MT
dc.contributor.authorGreene, MH
dc.contributor.authorGronwald, J
dc.contributor.authorOPAL Study Group,
dc.contributor.authorAOCS Group,
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHamann, U
dc.contributor.authorHansen, TVO
dc.contributor.authorHarris, HR
dc.contributor.authorHartman, M
dc.contributor.authorHeitz, F
dc.contributor.authorHildebrandt, MAT
dc.contributor.authorHøgdall, E
dc.contributor.authorHøgdall, CK
dc.contributor.authorHopper, JL
dc.contributor.authorHuang, R-Y
dc.contributor.authorHuff, C
dc.contributor.authorHulick, PJ
dc.contributor.authorHuntsman, DG
dc.contributor.authorImyanitov, EN
dc.contributor.authorKConFab Investigators,
dc.contributor.authorHEBON Investigators,
dc.contributor.authorIsaacs, C
dc.contributor.authorJakubowska, A
dc.contributor.authorJames, PA
dc.contributor.authorJanavicius, R
dc.contributor.authorJensen, A
dc.contributor.authorJohannsson, OT
dc.contributor.authorJohn, EM
dc.contributor.authorJones, ME
dc.contributor.authorKang, D
dc.contributor.authorKarlan, BY
dc.contributor.authorKarnezis, A
dc.contributor.authorKelemen, LE
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiemeney, LA
dc.contributor.authorKim, B-G
dc.contributor.authorKjaer, SK
dc.contributor.authorKomenaka, I
dc.contributor.authorKupryjanczyk, J
dc.contributor.authorKurian, AW
dc.contributor.authorKwong, A
dc.contributor.authorLambrechts, D
dc.contributor.authorLarson, MC
dc.contributor.authorLazaro, C
dc.contributor.authorLe, ND
dc.contributor.authorLeslie, G
dc.contributor.authorLester, J
dc.contributor.authorLesueur, F
dc.contributor.authorLevine, DA
dc.contributor.authorLi, L
dc.contributor.authorLi, J
dc.contributor.authorLoud, JT
dc.contributor.authorLu, KH
dc.contributor.authorLubiński, J
dc.contributor.authorMai, PL
dc.contributor.authorManoukian, S
dc.contributor.authorMarks, JR
dc.contributor.authorMatsuno, RK
dc.contributor.authorMatsuo, K
dc.contributor.authorMay, T
dc.contributor.authorMcGuffog, L
dc.contributor.authorMcLaughlin, JR
dc.contributor.authorMcNeish, IA
dc.contributor.authorMebirouk, N
dc.contributor.authorMenon, U
dc.contributor.authorMiller, A
dc.contributor.authorMilne, RL
dc.contributor.authorMinlikeeva, A
dc.contributor.authorModugno, F
dc.contributor.authorMontagna, M
dc.contributor.authorMoysich, KB
dc.contributor.authorMunro, E
dc.contributor.authorNathanson, KL
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorYie, JNY
dc.contributor.authorNielsen, HR
dc.contributor.authorNielsen, FC
dc.contributor.authorNikitina-Zake, L
dc.contributor.authorOdunsi, K
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorOlbrecht, S
dc.contributor.authorOlopade, OI
dc.contributor.authorOlson, SH
dc.contributor.authorOlsson, H
dc.contributor.authorOsorio, A
dc.contributor.authorPapi, L
dc.contributor.authorPark, SK
dc.contributor.authorParsons, MT
dc.contributor.authorPathak, H
dc.contributor.authorPedersen, IS
dc.contributor.authorPeixoto, A
dc.contributor.authorPejovic, T
dc.contributor.authorPerez-Segura, P
dc.contributor.authorPermuth, JB
dc.contributor.authorPeshkin, B
dc.contributor.authorPeterlongo, P
dc.contributor.authorPiskorz, A
dc.contributor.authorProkofyeva, D
dc.contributor.authorRadice, P
dc.contributor.authorRantala, J
dc.contributor.authorRiggan, MJ
dc.contributor.authorRisch, HA
dc.contributor.authorRodriguez-Antona, C
dc.contributor.authorRoss, E
dc.contributor.authorRossing, MA
dc.contributor.authorRunnebaum, I
dc.contributor.authorSandler, DP
dc.contributor.authorSantamariña, M
dc.contributor.authorSoucy, P
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSetiawan, VW
dc.contributor.authorShan, K
dc.contributor.authorSieh, W
dc.contributor.authorSimard, J
dc.contributor.authorSinger, CF
dc.contributor.authorSokolenko, AP
dc.contributor.authorSong, H
dc.contributor.authorSouthey, MC
dc.contributor.authorSteed, H
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorSutphen, R
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTan, YY
dc.contributor.authorTeixeira, MR
dc.contributor.authorTeo, SH
dc.contributor.authorTerry, KL
dc.contributor.authorTerry, MB
dc.contributor.authorOCAC Consortium,
dc.contributor.authorCIMBA Consortium,
dc.contributor.authorThomassen, M
dc.contributor.authorThompson, PJ
dc.contributor.authorThomsen, LCV
dc.contributor.authorThull, DL
dc.contributor.authorTischkowitz, M
dc.contributor.authorTitus, L
dc.contributor.authorToland, AE
dc.contributor.authorTorres, D
dc.contributor.authorTrabert, B
dc.contributor.authorTravis, R
dc.contributor.authorTung, N
dc.contributor.authorTworoger, SS
dc.contributor.authorValen, E
dc.contributor.authorvan Altena, AM
dc.contributor.authorvan der Hout, AH
dc.contributor.authorVan Nieuwenhuysen, E
dc.contributor.authorvan Rensburg, EJ
dc.contributor.authorVega, A
dc.contributor.authorEdwards, DV
dc.contributor.authorVierkant, RA
dc.contributor.authorWang, F
dc.contributor.authorWappenschmidt, B
dc.contributor.authorWebb, PM
dc.contributor.authorWeinberg, CR
dc.contributor.authorWeitzel, JN
dc.contributor.authorWentzensen, N
dc.contributor.authorWhite, E
dc.contributor.authorWhittemore, AS
dc.contributor.authorWinham, SJ
dc.contributor.authorWolk, A
dc.contributor.authorWoo, Y-L
dc.contributor.authorWu, AH
dc.contributor.authorYan, L
dc.contributor.authorYannoukakos, D
dc.contributor.authorZavaglia, KM
dc.contributor.authorZheng, W
dc.contributor.authorZiogas, A
dc.contributor.authorZorn, KK
dc.contributor.authorKleibl, Z
dc.contributor.authorEaston, D
dc.contributor.authorLawrenson, K
dc.contributor.authorDeFazio, A
dc.contributor.authorSellers, TA
dc.contributor.authorRamus, SJ
dc.contributor.authorPearce, CL
dc.contributor.authorMonteiro, AN
dc.contributor.authorCunningham, J
dc.contributor.authorGoode, EL
dc.contributor.authorSchildkraut, JM
dc.contributor.authorBerchuck, A
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorGayther, SA
dc.contributor.authorAntoniou, AC
dc.contributor.authorPharoah, PDP
dc.date.accessioned2022-04-01T13:39:20Z
dc.date.available2022-04-01T13:39:20Z
dc.date.issued2022-03-01
dc.identifier.citationEuropean journal of human genetics : EJHG, 2022, 30 (3), pp. 349 - 362
dc.identifier.issn1018-4813
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5063
dc.identifier.eissn1476-5438
dc.identifier.eissn1476-5438
dc.identifier.doi10.1038/s41431-021-00987-7
dc.identifier.doi10.1038/s41431-021-00987-7
dc.description.abstractPolygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.
dc.formatPrint-Electronic
dc.format.extent349 - 362
dc.languageeng
dc.language.isoeng
dc.publisherSPRINGERNATURE
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGEMO Study Collaborators
dc.subjectGC-HBOC Study Collaborators
dc.subjectEMBRACE Collaborators
dc.subjectOPAL Study Group
dc.subjectAOCS Group
dc.subjectKConFab Investigators
dc.subjectHEBON Investigators
dc.subjectOCAC Consortium
dc.subjectCIMBA Consortium
dc.titlePolygenic risk modeling for prediction of epithelial ovarian cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2021-09-27
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41431-021-00987-7
dc.relation.isPartOfEuropean journal of human genetics : EJHG
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume30
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
dc.contributor.icrauthorJones, Michael


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/