How Low Can You Go? The Radiobiology of Hypofractionation.
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Date
2022-05-01Author
Brand, DH
Kirby, AM
Yarnold, JR
Somaiah, N
Type
Journal Article
Metadata
Show full item recordAbstract
Hypofractionated radical radiotherapy is now an accepted standard of care for tumour sites such as prostate and breast cancer. Much research effort is being directed towards more profoundly hypofractionated (ultrahypofractionated) schedules, with some reaching UK standard of care (e.g. adjuvant breast). Hypofractionation exerts varying influences on each of the major clinical end points of radiotherapy studies: acute toxicity, late toxicity and local control. This review will discuss these effects from the viewpoint of the traditional 5 Rs of radiobiology, before considering non-canonical radiobiological effects that may be relevant to ultrahypofractionated radiotherapy. The principles outlined here may assist the reader in their interpretation of the wealth of clinical data presented in the tumour site-specific articles in this special issue.
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Subject
Breast
Humans
Breast Neoplasms
Prostatic Neoplasms
Treatment Outcome
Radiobiology
Male
Radiation Dose Hypofractionation
Research team
Breast Cancer Radiotherapy
Stereotactic and Precision Body Radiotherapy
Translational Breast Radiobiology
Language
eng
Date accepted
2022-02-11
Citation
Clinical oncology (Royal College of Radiologists (Great Britain)), 2022, 34 (5), pp. 280 - 287
Publisher
ELSEVIER SCIENCE LONDON