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Salvage stereotactic body radiotherapy (SBRT) for intraprostatic relapse after prostate cancer radiotherapy: An ESTRO ACROP Delphi consensus.

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ICR Author
van As, Nick
Tree, Alison
Author
Jereczek-Fossa, BA
Marvaso, G
Zaffaroni, M
Gugliandolo, SG
Zerini, D
Corso, F
Gandini, S
Alongi, F
Bossi, A
Cornford, P
De Bari, B
Fonteyne, V
Hoskin, P
Pieters, BR
Tree, AC
Arcangeli, S
Fuller, DB
Franzese, C
Hannoun-Levi, J-M
Janoray, G
Kerkmeijer, L
Kwok, Y
Livi, L
Loi, M
Miralbell, R
Pasquier, D
Pinkawa, M
Scher, N
Scorsetti, M
Shelan, M
Toledano, A
van As, N
Vavassori, A
Zilli, T
Pepa, M
Ost, P
on the behalf of the European Society for Radiotherapy, Oncology Advisory Committee on Radiation Oncology Practice (ESTRO ACROP)
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Type
Journal Article
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Abstract
<h4>Background and purpose</h4>Between 30% and 47% of patients treated with definitive radiotherapy (RT) for prostate cancer are at risk of intraprostatic recurrence during follow-up. Re-irradiation with stereotactic body RT (SBRT) is emerging as a feasible and safe therapeutic option. However, no consensus or guidelines exist on this topic. The purpose of this ESTRO ACROP project is to investigate expert opinion on salvage SBRT for intraprostatic relapse after RT.<h4>Materials and methods</h4>A 40-item questionnaire on salvage SBRT was prepared by an internal committee and reviewed by a panel of leading radiation oncologists plus a urologist expert in prostate cancer. Following the procedure of a Delphi consensus, 3 rounds of questionnaires were sent to selected experts on prostate re-irradiation.<h4>Results</h4>Among the 33 contacted experts, 18 (54.5%) agreed to participate. At the end of the final round, participants were able to find consensus on 14 out of 40 questions (35% overall) and major agreement on 13 questions (32.5% overall). Specifically, the consensus was reached regarding some selection criteria (no age limit, ECOG 0-1, satisfactory urinary flow), diagnostic procedures (exclusion of metastatic disease, SBRT target defined on the MRI) and therapeutic approach (no need for concomitant ADT, consideration of the first RT dose, validity of Phoenix criteria for salvage SBRT failure).<h4>Conclusion</h4>While awaiting the results of ongoing studies, our ESTRO ACROP Delphi consensus may serve as a practical guidance for salvage SBRT. Future research should address the existing disagreements on this promising approach.
URI
https://repository.icr.ac.uk/handle/internal/5164
DOI
https://doi.org/10.1016/j.ctrv.2021.102206
https://doi.org/10.1016/j.ctrv.2021.102206
 
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  • Radiotherapy and Imaging
Subject
on the behalf of the European Society for Radiotherapy, Oncology Advisory Committee on Radiation Oncology Practice (ESTRO ACROP)
Humans
Prostatic Neoplasms
Neoplasm Recurrence, Local
Salvage Therapy
Radiosurgery
Consensus
Male
Practice Guidelines as Topic
Research team
Stereotactic and Precision Body Radiotherapy
Language
eng
Date accepted
2021-04-02
Citation
Cancer treatment reviews, 2021, 98 pp. 102206 - ?

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