dc.contributor.author | Schiavoni, F | |
dc.contributor.author | Zuazua-Villar, P | |
dc.contributor.author | Roumeliotis, TI | |
dc.contributor.author | Benstead-Hume, G | |
dc.contributor.author | Pardo, M | |
dc.contributor.author | Pearl, FMG | |
dc.contributor.author | Choudhary, JS | |
dc.contributor.author | Downs, JA | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-06-17T12:36:07Z | |
dc.date.available | 2022-06-17T12:36:07Z | |
dc.date.issued | 2022-04-01 | |
dc.identifier | ARTN 1731 | |
dc.identifier | 10.1038/s41467-022-29420-3 | |
dc.identifier.citation | Nature Communications, 2022, 13 (1), pp. 1731 - | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5183 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-022-29420-3 | |
dc.description.abstract | Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the SWI/SNF chromatin remodelling complex is frequently lost in cancer. Here, we use a chromosomally stable cell line to test the effect of BRG1 loss on the evolution of aneuploidy. BRG1 deletion leads to an initial loss of fitness in this cell line that improves over time. Notably, we find increased tolerance to aneuploidy immediately upon loss of BRG1, and the fitness recovery over time correlates with chromosome gain. These data show that BRG1 loss creates an environment where karyotype changes can be explored without a fitness penalty. At least in some genetic backgrounds, therefore, BRG1 loss can affect the progression of tumourigenesis through tolerance of aneuploidy. | |
dc.format | Electronic | |
dc.format.extent | 1731 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | Nature Communications | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Aneuploidy | |
dc.subject | Cell Line | |
dc.subject | Chromatin Assembly and Disassembly | |
dc.subject | Chromosome Aberrations | |
dc.subject | Chromosomes | |
dc.subject | DNA Helicases | |
dc.subject | Humans | |
dc.subject | Nuclear Proteins | |
dc.subject | Transcription Factors | |
dc.title | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-03-16 | |
dc.date.updated | 2022-06-17T12:35:22Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41467-022-29420-3 | |
rioxxterms.licenseref.startdate | 2022-04-01 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35365638 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.publication-status | Published online | |
pubs.volume | 13 | |
icr.researchteam | Functional Proteomics | |
icr.researchteam | Prote & Metabolomics Fac | |
icr.researchteam | Genome Stability | |
dc.contributor.icrauthor | Roumeliotis, Theodoros | |
dc.contributor.icrauthor | Pardo Calvo, Maria Mercedes | |
dc.contributor.icrauthor | Choudhary, Jyoti | |
dc.contributor.icrauthor | Downs, Jessica | |