Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK.
Abstract
We present the first young paediatric patient with desmoplastic small round cell tumour (DSRCT) treated in UK with hyperthermic intraperitoneal chemotherapy (HIPEC). A 7-year-old girl was diagnosed with abdominal DSRCT with peritoneal and liver metastases. After six cycles of chemotherapy she obtained a partial response, including almost complete resolution of the two liver metastases. It was decided to pursue cytoreductive surgery (CRS) combined with HIPEC, a procedure commonly performed in adults, but seldom in a child. The surgery was macroscopically complete and the HIPEC uncomplicated. She continued treatment without delays, including whole abdomino-pelvic radiotherapy and maintenance chemotherapy (cyclophosphamide/vinorelbine for 12 months). She is currently in complete remission 4 months after end of treatment and 26 months after diagnosis. HIPEC was made possible by successful collaboration between multiple teams. CRS-HIPEC proved to be safe and feasible and could be offered to other children with diagnoses of peritoneal malignancies across the UK.
Collections
Subject
malignant disease and immunosuppression
paediatric oncology
paediatrics (drugs and medicines)
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Child
Cisplatin
Cyclophosphamide
Cytoreduction Surgical Procedures
Desmoplastic Small Round Cell Tumor
Doxorubicin
Etoposide
Female
Humans
Hyperthermic Intraperitoneal Chemotherapy
Ifosfamide
Liver Neoplasms
Maintenance Chemotherapy
Neoadjuvant Therapy
Pelvic Neoplasms
Peritoneal Neoplasms
Radiotherapy
Remission Induction
United Kingdom
Vincristine
Vinorelbine
Language
eng
Date accepted
2020-12-05
License start date
2021-01-28
Citation
BMJ Case Reports, 2021, 14 (1), pp. e234876 -
Publisher
BMJ PUBLISHING GROUP