dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Bruce, C | |
dc.contributor.author | Cooke, R | |
dc.contributor.author | Coulson, P | |
dc.contributor.author | Jones, ME | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-07-19T10:14:59Z | |
dc.date.available | 2022-07-19T10:14:59Z | |
dc.date.issued | 2022-05-17 | |
dc.identifier | ARTN 29 | |
dc.identifier | 10.1186/s13058-022-01517-z | |
dc.identifier.citation | Breast Cancer Research, 2022, 24 (1), pp. 29 - | en_US |
dc.identifier.issn | 1465-5411 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5240 | |
dc.identifier.eissn | 1465-542X | |
dc.identifier.eissn | 1465-542X | |
dc.identifier.doi | 10.1186/s13058-022-01517-z | |
dc.description.abstract | PURPOSE: Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case-control study, the relation of risk of breast cancer in men to infertility and number of children. PATIENTS AND METHODS: We conducted a national case-control study in England and Wales, interviewing 1998 cases incident 2005-17 and 1597 male controls, which included questions on infertility and offspring. RESULTS: Risk of breast cancer was statistically significantly associated with male-origin infertility (OR = 2.03 (95% confidence interval (CI) 1.18-3.49)) but not if a couple's infertility had been diagnosed as of origin from the female partner (OR = 0.86 (0.51-1.45)). Risk was statistically significantly raised for men who had not fathered any children (OR = 1.50 (95% CI 1.21-1.86)) compared with men who were fathers. These associations were statistically significantly present for invasive tumours but not statistically significant for in situ tumours. CONCLUSION: Our data give strong evidence that risk of breast cancer is increased for men who are infertile. The reason is not clear and needs investigation. | |
dc.format | Electronic | |
dc.format.extent | 29 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartof | Breast Cancer Research | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Breast cancer | |
dc.subject | Case–control | |
dc.subject | Infertility | |
dc.subject | Male | |
dc.subject | Breast Neoplasms, Male | |
dc.subject | Case-Control Studies | |
dc.subject | England | |
dc.subject | Humans | |
dc.subject | Infertility, Male | |
dc.subject | Male | |
dc.subject | Risk Factors | |
dc.subject | Wales | |
dc.title | Infertility and risk of breast cancer in men: a national case-control study in England and Wales. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-03-07 | |
dc.date.updated | 2022-07-19T10:14:35Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1186/s13058-022-01517-z | en_US |
rioxxterms.licenseref.startdate | 2022-05-17 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35578306 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published online | |
pubs.volume | 24 | |
icr.researchteam | Aetiological Epidemiology | en_US |
dc.contributor.icrauthor | Jones, Michael | |
icr.provenance | Deposited by Mr Arek Surman on 2022-07-19. Deposit type is initial. No. of files: 1. Files: Infertility and risk of breast cancer in men a national case-control study in England and Wales.pdf | |