dc.contributor.author | Ingle, M | |
dc.contributor.author | Blackledge, M | |
dc.contributor.author | White, I | |
dc.contributor.author | Wetscherek, A | |
dc.contributor.author | Lalondrelle, S | |
dc.contributor.author | Hafeez, S | |
dc.contributor.author | Bhide, S | |
dc.coverage.spatial | Netherlands | |
dc.date.accessioned | 2022-09-06T11:36:27Z | |
dc.date.available | 2022-09-06T11:36:27Z | |
dc.date.issued | 2022-07-01 | |
dc.identifier | S2405-6316(22)00051-3 | |
dc.identifier.citation | Physics and Imaging in Radiation Oncology, 2022, 23 pp. 32 - 37 | |
dc.identifier.issn | 2405-6316 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5416 | |
dc.identifier.eissn | 2405-6316 | |
dc.identifier.eissn | 2405-6316 | |
dc.identifier.doi | 10.1016/j.phro.2022.06.003 | |
dc.description.abstract | BACKGROUND AND PURPOSE: Magnetic resonance imaging integrated linear accelerator (MR-Linac) platforms enable acquisition of diffusion weighted imaging (DWI) during treatment providing potential information about treatment response. Obtaining DWI on these platforms is technically different from diagnostic magnetic resonance imaging (MRI) scanners. The aim of this project was to determine feasibility of obtaining DWI and calculating apparent diffusion coefficient (ADC) parameters longitudinally in rectal cancer patients on the MR-Linac. MATERIALS AND METHODS: Nine patients undergoing treatment on MR-Linac had DWI acquired using b-values 0, 30, 150, 500 s/mm2. Gross tumour volume (GTV) and normal tissue was delineated on DWI throughout treatment and median ADC was calculated using an in-house tool (pyOsirix ®). RESULTS: Seven out of nine patients were included in the analysis; all demonstrated downstaging at follow-up. A total of 63 out of 70 DWI were analysed (7 excluded due to poor image quality). An increasing trend of ADC median for GTV (1.15 × 10-3 mm2/s interquartile range (IQ): 1.05-1.17 vs 1.59 × 10-3 mm2/s IQ: 1.37 - 1.64; p = 0.0156), correlating to treatment response. In comparison ADC median for normal tissue remained the same between first and last fraction (1.61 × 10-3 mm2/s IQ: 1.56-1.71 vs 1.67 × 10-3 mm2/s IQ: 1.37-2.00; p = 0.9375). CONCLUSIONS: DWI assessment in rectal cancer patients on MR-Linac is feasible. Initial results provide foundations for further studies to determine DWI use for treatment adaptation in rectal cancer. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 32 - 37 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.relation.ispartof | Physics and Imaging in Radiation Oncology | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Apparent diffusion coefficient | |
dc.subject | Diffusion weighted imaging | |
dc.subject | MR-Linac | |
dc.subject | MRI | |
dc.subject | Rectal cancer | |
dc.title | Quantitative analysis of diffusion weighted imaging in rectal cancer during radiotherapy using a magnetic resonance imaging integrated linear accelerator. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-06-02 | |
dc.date.updated | 2022-09-06T11:00:53Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.phro.2022.06.003 | |
rioxxterms.licenseref.startdate | 2022-07-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35756883 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer/Gynaecological Cancer (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance Imaging in Radiotherapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Computational Imaging | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/19/20 Starting Cohort | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.phro.2022.06.003 | |
pubs.volume | 23 | |
icr.researchteam | Gynaecological Cancer | |
icr.researchteam | Computational Imaging | |
icr.researchteam | Magnet Resonance Imaging | |
icr.researchteam | Clinic Acad RT Huddart | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Ingle, Manasi | |
dc.contributor.icrauthor | Blackledge, Matthew | |
dc.contributor.icrauthor | Wetscherek, Andreas | |
dc.contributor.icrauthor | Hafeez, Shaista | |
dc.contributor.icrauthor | Bhide, Shreerang | |
icr.provenance | Deposited by Dr Shree Bhide on 2022-09-06. Deposit type is initial. No. of files: 1. Files: Quantitative analysis of diffusion weighted imaging in rectal cancer during radiotherapy using a magnetic resonance imaging .pdf | |