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dc.contributor.authorPanek, R
dc.contributor.authorWelsh, L
dc.contributor.authorBaker, LCJ
dc.contributor.authorSchmidt, MA
dc.contributor.authorWong, KH
dc.contributor.authorRiddell, AM
dc.contributor.authorKoh, D-M
dc.contributor.authorDunlop, A
dc.contributor.authorMcquaid, D
dc.contributor.authord'Arcy, JA
dc.contributor.authorBhide, SA
dc.contributor.authorHarrington, KJ
dc.contributor.authorNutting, CM
dc.contributor.authorHopkinson, G
dc.contributor.authorRichardson, C
dc.contributor.authorBox, C
dc.contributor.authorEccles, SA
dc.contributor.authorLeach, MO
dc.contributor.authorRobinson, SP
dc.contributor.authorNewbold, KL
dc.date.accessioned2017-04-03T10:04:37Z
dc.date.issued2017-08-01
dc.identifier.citationClinical cancer research : an official journal of the American Association for Cancer Research, 2017, 23 (15), pp. 4233 - 4241
dc.identifier.issn1078-0432
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/547
dc.identifier.eissn1557-3265
dc.identifier.doi10.1158/1078-0432.ccr-16-1209
dc.description.abstractPurpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and patients.Experimental Design: Quantitation of the transverse relaxation rate, R2*, which is sensitive to paramagnetic deoxyhemoglobin, using serial IS-MRI acquisitions, was used to monitor temporal oscillations in levels of paramagnetic deoxyhemoglobin in human CALR xenografts and patients with HNSCC at 3T. Autocovariance and power spectrum analysis of variations in R2* was performed for each imaged voxel, to assess statistical significance and frequencies of cycling changes in tumor blood oxygenation. Pathologic correlates with tumor perfusion (Hoechst 33342), hypoxia (pimonidazole), and vascular density (CD31) were sought in the xenografts, and dynamic contrast-enhanced (DCE) MRI was used to assess patient tumor vascularization. The prevalence of fluctuations within patient tumors, DCE parameters, and treatment outcome were reported.Results: Spontaneous R2* fluctuations with a median periodicity of 15 minutes were detected in both xenografts and patient tumors. Spatially, these fluctuations were predominantly associated with regions of heterogeneous perfusion and hypoxia in the CALR xenografts. In patients, R2* fluctuations spatially correlated with regions of lymph nodes with low Ktrans values, typically in the vicinity of necrotic cores.Conclusions: IS-MRI can be used to monitor variations in levels of paramagnetic deoxyhemoglobin, associated with cycling hypoxia. The presence of such fluctuations may be linked with impaired tumor vasculature, the presence of which may impact treatment outcome. Clin Cancer Res; 23(15); 4233-41. ©2017 AACR.
dc.formatPrint-Electronic
dc.format.extent4233 - 4241
dc.languageeng
dc.language.isoeng
dc.publisherAMER ASSOC CANCER RESEARCH
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectLymph Nodes
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectCarcinoma, Squamous Cell
dc.subjectHead and Neck Neoplasms
dc.subjectNeovascularization, Pathologic
dc.subjectNitroimidazoles
dc.subjectContrast Media
dc.subjectMagnetic Resonance Imaging
dc.subjectTreatment Outcome
dc.subjectXenograft Model Antitumor Assays
dc.subjectCell Hypoxia
dc.subjectRadiation Tolerance
dc.subjectFemale
dc.subjectMale
dc.subjectSquamous Cell Carcinoma of Head and Neck
dc.titleNoninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.
dc.typeJournal Article
dcterms.dateAccepted2017-03-03
rioxxterms.versionofrecord10.1158/1078-0432.ccr-16-1209
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfClinical cancer research : an official journal of the American Association for Cancer Research
pubs.issue15
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume23
pubs.embargo.termsNot known
icr.researchteamMagnetic Resonance
icr.researchteamPre-Clinical MRI
icr.researchteamRadiotherapy Physics Modelling
icr.researchteamTargeted Therapy
dc.contributor.icrauthorBaker, Lauren
dc.contributor.icrauthorHarrington, Kevin
dc.contributor.icrauthorBox, Carol
dc.contributor.icrauthorLeach, Martin
dc.contributor.icrauthorRobinson, Simon


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