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dc.contributor.authorBabina, IS
dc.contributor.authorTurner, NC
dc.date.accessioned2017-04-03T10:12:11Z
dc.date.issued2016-11-18
dc.identifier.citationNature reviews. Cancer, 2017, 17 (5), pp. 318 - 332
dc.identifier.issn1474-175X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/549
dc.identifier.eissn1474-1768
dc.identifier.doi10.1038/nrc.2017.8
dc.description.abstractFibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed results with FGFR-targeted cancer therapies, revealing substantial complexity to targeting aberrant FGFR signalling. In this Review, we discuss the increasing understanding of the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting.
dc.formatPrint-Electronic
dc.format.extent318 - 332
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectFibroblast Growth Factors
dc.subjectReceptors, Fibroblast Growth Factor
dc.subjectAntineoplastic Agents
dc.subjectSignal Transduction
dc.subjectMolecular Targeted Therapy
dc.titleAdvances and challenges in targeting FGFR signalling in cancer.
dc.typeJournal Article
dcterms.dateAccepted2016-11-18
rioxxterms.versionofrecord10.1038/nrc.2017.8
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature reviews. Cancer
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNot known
icr.researchteamMolecular Oncology
dc.contributor.icrauthorBabina, Irina
dc.contributor.icrauthorTurner, Nicholas


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