Advances and challenges in targeting FGFR signalling in cancer.
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Date
2016-11-18Author
Babina, IS
Turner, NC
Type
Journal Article
Metadata
Show full item recordAbstract
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed results with FGFR-targeted cancer therapies, revealing substantial complexity to targeting aberrant FGFR signalling. In this Review, we discuss the increasing understanding of the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting.
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Subject
Animals
Humans
Neoplasms
Fibroblast Growth Factors
Receptors, Fibroblast Growth Factor
Antineoplastic Agents
Signal Transduction
Molecular Targeted Therapy
Research team
Molecular Oncology
Language
eng
Date accepted
2016-11-18
License start date
2017-05
Citation
Nature reviews. Cancer, 2017, 17 (5), pp. 318 - 332
Publisher
NATURE PORTFOLIO