US Backscatter for Liver Fat Quantification: An AIUM-RSNA QIBA Pulse-Echo Quantitative Ultrasound Initiative.
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Date
2022-12-01ICR Author
Author
Wear, KA
Han, A
Rubin, JM
Gao, J
Lavarello, R
Cloutier, G
Bamber, J
Tuthill, T
Type
Journal Article
Metadata
Show full item recordAbstract
Nonalcoholic fatty liver disease (NAFLD) is believed to affect one-third of American adults. Noninvasive methods that enable detection and monitoring of NAFLD have the potential for great public health benefits. Because of its low cost, portability, and noninvasiveness, US is an attractive alternative to both biopsy and MRI in the assessment of liver steatosis. NAFLD is qualitatively associated with enhanced B-mode US echogenicity, but visual measures of B-mode echogenicity are negatively affected by interobserver variability. Alternatively, quantitative backscatter parameters, including the hepatorenal index and backscatter coefficient, are being investigated with the goal of improving US-based characterization of NAFLD. The American Institute of Ultrasound in Medicine and Radiological Society of North America Quantitative Imaging Biomarkers Alliance are working to standardize US acquisition protocols and data analysis methods to improve the diagnostic performance of the backscatter coefficient in liver fat assessment. This review article explains the science and clinical evidence underlying backscatter for liver fat assessment. Recommendations for data collection are discussed, with the aim of minimizing potential confounding effects associated with technical and biologic variables.
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Subject
Adult
Humans
Non-alcoholic Fatty Liver Disease
Prospective Studies
Liver
Ultrasonography
Magnetic Resonance Imaging
Research team
Ultrasound & Optic Imag
Language
eng
Date accepted
2022-07-08
License start date
2022-12-01
Citation
Radiology, 2022, 305 (3), pp. 526 - 537
Publisher
RADIOLOGICAL SOC NORTH AMERICA (RSNA)