dc.contributor.author | Adusumilli, VS | |
dc.contributor.author | Walker, TL | |
dc.contributor.author | Overall, RW | |
dc.contributor.author | Klatt, GM | |
dc.contributor.author | Zeidan, SA | |
dc.contributor.author | Zocher, S | |
dc.contributor.author | Kirova, DG | |
dc.contributor.author | Ntitsias, K | |
dc.contributor.author | Fischer, TJ | |
dc.contributor.author | Sykes, AM | |
dc.contributor.author | Reinhardt, S | |
dc.contributor.author | Dahl, A | |
dc.contributor.author | Mansfeld, J | |
dc.contributor.author | Rünker, AE | |
dc.contributor.author | Kempermann, G | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-01-23T14:14:20Z | |
dc.date.available | 2023-01-23T14:14:20Z | |
dc.date.issued | 2021-02-04 | |
dc.identifier | S1934-5909(20)30538-5 | |
dc.identifier.citation | Cell Stem Cell, 2021, 28 (2), pp. 300 - 314.e6 | |
dc.identifier.issn | 1934-5909 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5660 | |
dc.identifier.eissn | 1875-9777 | |
dc.identifier.eissn | 1875-9777 | |
dc.identifier.doi | 10.1016/j.stem.2020.10.019 | |
dc.description.abstract | Cellular redox states regulate the balance between stem cell maintenance and activation. Increased levels of intracellular reactive oxygen species (ROS) are linked to proliferation and lineage specification. In contrast to this general principle, we here show that in the hippocampus of adult mice, quiescent neural precursor cells (NPCs) maintain the highest ROS levels (hiROS). Classifying NPCs on the basis of cellular ROS content identified distinct functional states. Shifts in ROS content primed cells for a subsequent state transition, with lower ROS content marking proliferative activity and differentiation. Physical activity, a physiological activator of adult hippocampal neurogenesis, recruited hiROS NPCs into proliferation via a transient Nox2-dependent ROS surge. In the absence of Nox2, baseline neurogenesis was unaffected, but the activity-induced increase in proliferation disappeared. These results provide a metabolic classification of NPC functional states and describe a mechanism linking the modulation of cellular ROS by behavioral cues to the activation of adult NPCs. | |
dc.format | Print-Electronic | |
dc.format.extent | 300 - 314.e6 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.relation.ispartof | Cell Stem Cell | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | adult neurogenesis | |
dc.subject | adult stem cells | |
dc.subject | physical activity | |
dc.subject | quiescent neural stem cells | |
dc.subject | reactive oxygen species | |
dc.subject | stem cell heterogeneity | |
dc.subject | Animals | |
dc.subject | Cell Differentiation | |
dc.subject | Cell Proliferation | |
dc.subject | Hippocampus | |
dc.subject | Mice | |
dc.subject | Neural Stem Cells | |
dc.subject | Neurogenesis | |
dc.subject | Reactive Oxygen Species | |
dc.title | ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-10-29 | |
dc.date.updated | 2023-01-23T13:38:21Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.stem.2020.10.019 | |
rioxxterms.licenseref.startdate | 2021-02-04 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33275875 | |
pubs.issue | 2 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Post-translational modifications and cell proliferation | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.stem.2020.10.019 | |
pubs.volume | 28 | |
icr.researchteam | Post-transl modification | |
dc.contributor.icrauthor | Mansfeld, Joerg | |
icr.provenance | Deposited by Dr Joerg Mansfeld on 2023-01-23. Deposit type is initial. No. of files: 2. Files: 1-s2.0-S1934590920305385-main.pdf; ScienceDirect_files_23Jan2023_13-37-47.877.zip | |