dc.contributor.author | Jones, I | |
dc.contributor.author | Dent, L | |
dc.contributor.author | Higo, T | |
dc.contributor.author | Roumeliotis, T | |
dc.contributor.author | Arias Garcia, M | |
dc.contributor.author | Shree, H | |
dc.contributor.author | Choudhary, J | |
dc.contributor.author | Pedersen, M | |
dc.contributor.author | Bakal, C | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-04-19T10:19:02Z | |
dc.date.available | 2023-04-19T10:19:02Z | |
dc.date.issued | 2023-01-25 | |
dc.identifier | ARTN eadd0636 | |
dc.identifier.citation | Science Advances, 2023, 9 (4), pp. eadd0636 - | |
dc.identifier.issn | 2375-2548 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5753 | |
dc.identifier.eissn | 2375-2548 | |
dc.identifier.eissn | 2375-2548 | |
dc.identifier.doi | 10.1126/sciadv.add0636 | |
dc.description.abstract | Almost all living cells maintain size uniformity through successive divisions. Proteins that over and underscale with size can act as rheostats, which regulate cell cycle progression. Using a multiomic strategy, we leveraged the heterogeneity of melanoma cell lines to identify peptides, transcripts, and phosphorylation events that differentially scale with cell size. Subscaling proteins are enriched in regulators of the DNA damage response and cell cycle progression, whereas super-scaling proteins included regulators of the cytoskeleton, extracellular matrix, and inflammatory response. Mathematical modeling suggested that decoupling growth and proliferative signaling may facilitate cell cycle entry over senescence in large cells when mitogenic signaling is decreased. Regression analysis reveals that up-regulation of TP53 or CDKN1A/p21CIP1 is characteristic of proliferative cancer cells with senescent-like sizes/proteomes. This study provides one of the first demonstrations of size-scaling phenomena in cancer and how morphology influences the chemistry of the cell. | |
dc.format | Print-Electronic | |
dc.format.extent | eadd0636 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | |
dc.relation.ispartof | Science Advances | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Humans | |
dc.subject | Proteome | |
dc.subject | Melanoma | |
dc.subject | Cell Cycle | |
dc.subject | Cell Line | |
dc.subject | Cell Proliferation | |
dc.subject | Cellular Senescence | |
dc.title | Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-12-19 | |
dc.date.updated | 2023-04-18T07:39:23Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1126/sciadv.add0636 | |
rioxxterms.licenseref.startdate | 2023-01-25 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36696495 | |
pubs.issue | 4 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/19/20 Starting Cohort | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1126/sciadv.add0636 | |
pubs.volume | 9 | |
icr.researchteam | Dynamical Cell Systems | |
icr.researchteam | Functional Proteomics | |
icr.researchteam | Prote & Metabolomics Fac | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Jones, Ian | |
dc.contributor.icrauthor | Roumeliotis, Theodoros | |
dc.contributor.icrauthor | Choudhary, Jyoti | |
dc.contributor.icrauthor | Pedersen, Malin | |
dc.contributor.icrauthor | Bakal, Christopher | |
icr.provenance | Deposited by Dr Theo Roumeliotis on 2023-04-18. Deposit type is initial. No. of files: 1. Files: Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer.pdf | |