Browsing Genetics and Epidemiology by author "Jones, Michael"
Now showing items 61-72 of 72
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Prioritisation by FIT to mitigate the impact of delays in the 2-week wait colorectal cancer referral pathway during the COVID-19 pandemic: a UK modelling study.
Loveday, C; Sud, A; Jones, ME; Broggio, J; Scott, S; et al. (BMJ PUBLISHING GROUP, 2020-08-27)OBJECTIVE: To evaluate the impact of faecal immunochemical testing (FIT) prioritisation to mitigate the impact of delays in the colorectal cancer (CRC) urgent diagnostic (2-week-wait (2WW)) pathway consequent from the ... -
Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups.
Abubakar, M; Orr, N; Daley, F; Coulson, P; Ali, HR; et al. (BIOMED CENTRAL LTD, 2016-10-18)BACKGROUND: The value of KI67 in breast cancer prognostication has been questioned due to concerns on the analytical validity of visual KI67 assessment and methodological limitations of published studies. Here, we investigate ... -
Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom.
Schoemaker, MJ; Jones, ME; Wright, LB; Griffin, J; McFadden, E; et al. (BIOMED CENTRAL LTD, 2016-07-15)BACKGROUND: Women diagnosed with breast cancer frequently attribute their cancer to psychological stress, but scientific evidence is inconclusive. We investigated whether experienced frequency of stress and adverse life ... -
Rare germline copy number variants (CNVs) and breast cancer risk.
Dennis, J; Tyrer, JP; Walker, LC; Michailidou, K; Dorling, L; et al. (NATURE PORTFOLIO, 2022-01-18)Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding ... -
Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.
Brouckaert, O; Rudolph, A; Laenen, A; Keeman, R; Bolla, MK; et al. (BMC, 2017-12-01)BACKGROUND: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors ... -
Risk of breast cancer in men in relation to weight change: A national case-control study in England and Wales.
Swerdlow, AJ; Bruce, C; Cooke, R; Coulson, P; Schoemaker, MJ; et al. (WILEY, 2022-06-01)Breast cancer is uncommon in men and knowledge about its causation limited. Obesity is a risk factor but there has been no investigation of whether weight change is an independent risk factor, as it is in women. In a ... -
Risk of thyroid disorders in adult and childhood Hodgkin lymphoma survivors 40 years after treatment.
Macklin-Doherty, A; Jones, M; Coulson, P; Bruce, C; Chau, I; et al. (TAYLOR & FRANCIS LTD, 2022-02-23)Thyroid abnormalities are well reported following childhood treatment for Hodgkin Lymphoma (HL). Limited information exists for adult patients and after modern treatments. We analyzed risks of thyroid disorders in 237 ... -
Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation.
Williams, CL; Jones, ME; Swerdlow, AJ; Botting, BJ; Davies, MC; et al. (BMJ PUBLISHING GROUP, 2018-07-11)OBJECTIVE: To investigate the risks of ovarian, breast, and corpus uteri cancer in women who have had assisted reproduction. DESIGN: Large, population based, data linkage cohort study. SETTING AND PARTICIPANTS: All women ... -
Smoking and risk of breast cancer in the Generations Study cohort.
Jones, ME; Schoemaker, MJ; Wright, LB; Ashworth, A; Swerdlow, AJ (BMC, 2017-11-22)BACKGROUND: Plausible biological reasons exist regarding why smoking could affect breast cancer risk, but epidemiological evidence is inconsistent. METHODS: We used serial questionnaire information from the Generations ... -
The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium.
Nichols, HB; Schoemaker, MJ; Wright, LB; McGowan, C; Brook, MN; et al. (AMER ASSOC CANCER RESEARCH, 2017-09-01)Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal ... -
The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3).
Trabert, B; Tworoger, SS; O'Brien, KM; Townsend, MK; Fortner, RT; et al. (AMER ASSOC CANCER RESEARCH, 2020-03-01)Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses ... -
Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study.
Bodicoat, DH; Schoemaker, MJ; Jones, ME; McFadden, E; Griffin, J; et al. (BIOMED CENTRAL LTD, 2014-02-04)INTRODUCTION: Breast development and hormonal changes at puberty might affect breast cancer risk, but epidemiological analyses have focussed largely on age at menarche and not at other pubertal stages. METHODS: We investigated ...