Browsing Genetics and Epidemiology by author "Mitchell, Jonathan"
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Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site
D'Annessa, I; Coletta, A; Sutthibutpong, T; Mitchell, J; Chillemi, G; et al. (Oxford University Press (OUP), 2014-08-18)Human topoisomerase 1B has been simulated covalently bound to a negatively supercoiled DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA duplex. The presence of the more realistic supercoiled ...