Browsing Genetics and Epidemiology by author "Mijuskovic, Martina"
Now showing items 1-1 of 1
-
Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus
Mijušković, M; Chou, Y-F; Gigi, V; Lindsay, CR; Shestova, O; et al. (Elsevier BV, 2015-09-01)Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncated Rag2 revealed numerous off-target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors ...