Now showing items 1-2 of 2

    • Germline MBD4 deficiency causes a multi-tumor predisposition syndrome. 

      Palles, C; West, HD; Chew, E; Galavotti, S; Flensburg, C; et al. (CELL PRESS, 2022-05-05)
      We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4. We identified five individuals with bi-allelic ...
    • Phenotypic noise and plasticity in cancer evolution. 

      Whiting, FJH; Househam, J; Baker, A-M; Sottoriva, A; Graham, TA (Elsevier BV, 2023-11-13)
      Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these phenomena can influence a cell's fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions ...