Browsing Genetics and Epidemiology by author "Al-Lazikani, Bissan"

Now showing items 1-2 of 2

    • Leveraging Human Genetics to Guide Cancer Drug Development. 

      Kinnersley, B; Sud, A; Coker, EA; Tym, JE; Di Micco, P; et al. (AMER SOC CLINICAL ONCOLOGY, 2018-11-21)
      PURPOSE: The high attrition rate of cancer drug development programs is a barrier to realizing the promise of precision oncology. We have examined whether the genetic insights from genome-wide association studies of cancer ...

    • Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. 

      Wedge, DC; Gundem, G; Mitchell, T; Woodcock, DJ; Martincorena, I; et al. (NATURE PUBLISHING GROUP, 2018-05-01)
      Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer ...