dc.contributor.author | Wong, K | |
dc.contributor.author | Kinsella, N | |
dc.contributor.author | Seth, J | |
dc.contributor.author | Nicol, D | |
dc.contributor.author | Cahill, D | |
dc.contributor.author | Kasivisvanathan, R | |
dc.contributor.author | Withington, J | |
dc.contributor.author | Moghul, M | |
dc.contributor.author | Moss, CL | |
dc.contributor.author | Van Hemelrijck, M | |
dc.contributor.author | Giorgakoudi, K | |
dc.contributor.author | Cottrell, C | |
dc.contributor.author | Yates, E | |
dc.contributor.author | Khoo, V | |
dc.contributor.author | James, ND | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-11-07T14:42:24Z | |
dc.date.available | 2023-11-07T14:42:24Z | |
dc.date.issued | 2023-10-06 | |
dc.identifier | bmjopen-2023-076621 | |
dc.identifier.citation | BMJ Open, 2023, 13 (10), pp. e076621 - | |
dc.identifier.issn | 2044-6055 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6039 | |
dc.identifier.eissn | 2044-6055 | |
dc.identifier.eissn | 2044-6055 | |
dc.identifier.doi | 10.1136/bmjopen-2023-076621 | |
dc.identifier.doi | 10.1136/bmjopen-2023-076621 | |
dc.description.abstract | INTRODUCTION: Patients undergoing prostate radiotherapy with an enlarged prostate can have short-term and long-term urinary complications. Currently, transurethral resection of the prostate (TURP) is the mainstay surgical intervention for men with urinary symptoms due to an enlarged prostate prior to radiotherapy. UroLift (NeoTract, Pleasanton, CA, USA) is a recent minimally invasive alternative, widely used in benign disease but is untested in men with prostate cancer. METHODS AND ANALYSIS: A multicentre, two-arm study designed in collaboration with a Patient Reference Group to assess the feasibility of randomising men with prostate cancer and coexisting urinary symptoms due to prostate enlargement to TURP or UroLift ahead of radiotherapy. 45 patients will be enrolled and randomised (1:1) using a computer-generated programme to TURP or UroLift. Recruitment and retention will be assessed over a 12 month period. Information on clinical outcomes, adverse events and costs will be collected. Clinical outcomes and patient reported outcome measures will be measured at baseline, 6 weeks postintervention and 3 months following radiotherapy. A further 12 in-depth interviews will be conducted with a subset of patients to assess acceptability using the Theoretical Framework of Acceptability. Descriptive analysis on all outcomes will be performed using Stata (StataCorp V.2021). ETHICS AND DISSEMINATION: The trial has been approved by the Research Ethics Committee (REC) NHS Health Research Authority (HRA) and Health and Care Research Wales (HCRW). The results will be published in peer-reviewed journals, presented at national meetings and disseminated to patients via social media, charity and hospital websites. TRIAL REGISTRATION NUMBER: NCT05840549. | |
dc.format | Electronic | |
dc.format.extent | e076621 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMJ PUBLISHING GROUP | |
dc.relation.ispartof | BMJ Open | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
dc.subject | Magnetic resonance imaging | |
dc.subject | ONCOLOGY | |
dc.subject | Prostate disease | |
dc.subject | RADIOTHERAPY | |
dc.subject | Urological tumours | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Feasibility Studies | |
dc.subject | London | |
dc.subject | Prostate | |
dc.subject | Prostatic Hyperplasia | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Transurethral Resection of Prostate | |
dc.subject | Randomized Controlled Trials as Topic | |
dc.title | COmparing Urolift and Standard Transurethral resection of prostate Ahead of Radiotherapy in men with urinary symptoms secondary to prostate enlargement in Southwest London and North Cumbria (CO-STAR): a study protocol for a randomised feasibility study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-08-09 | |
dc.date.updated | 2023-10-31T17:06:08Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1136/bmjopen-2023-076621 | |
rioxxterms.licenseref.startdate | 2023-10-06 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37802612 | |
pubs.issue | 10 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Prostate and Bladder Cancer Research | |
pubs.organisational-group | ICR/ImmNet | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1136/bmjopen-2023-076621 | |
pubs.volume | 13 | |
icr.researchteam | Prostate & Bladder Cancer | |
dc.contributor.icrauthor | Moghul, Masood | |
dc.contributor.icrauthor | James, Nicholas | |
icr.provenance | Deposited by Prof Nick James on 2023-10-31. Deposit type is initial. No. of files: 1. Files: bCObmparing Urolift and bSbtandard bTbransurethral resection of prostate bAbhead of bRbadiotherapy in men with urinary sympt.pdf | |