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Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings.

dc.contributor.authorNguyen, KD
dc.contributor.authorAmerio, A
dc.contributor.authorAguglia, A
dc.contributor.authorMagnani, L
dc.contributor.authorParise, A
dc.contributor.authorConio, B
dc.contributor.authorSerafini, G
dc.contributor.authorAmore, M
dc.contributor.authorCostanza, A
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-11-08T11:52:40Z
dc.date.available2023-11-08T11:52:40Z
dc.date.issued2023-08-19
dc.identifierARTN 2099
dc.identifiercells12162099
dc.identifier.citationCells, 2023, 12 (16), pp. 2099 -
dc.identifier.issn2073-4409
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/6053
dc.identifier.eissn2073-4409
dc.identifier.eissn2073-4409
dc.identifier.doi10.3390/cells12162099
dc.identifier.doi10.3390/cells12162099
dc.description.abstractSchizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.
dc.formatElectronic
dc.format.extent2099 -
dc.languageeng
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofCells
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectclinical correlates
dc.subjectimmunological dysfunction
dc.subjectmicroglia
dc.subjectneuroinflammation
dc.subjectschizophrenia
dc.subjectHumans
dc.subjectSchizophrenia
dc.subjectMicroglia
dc.subjectGenetic Association Studies
dc.titleMicroglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings.
dc.typeJournal Article
dcterms.dateAccepted2023-08-17
dc.date.updated2023-11-08T11:52:05Z
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/cells12162099
rioxxterms.licenseref.startdate2023-08-19
rioxxterms.typeJournal Article/Review
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37626909
pubs.issue16
pubs.organisational-groupICR
pubs.organisational-groupICR/Primary Group
pubs.organisational-groupICR/Primary Group/ICR Divisions
pubs.organisational-groupICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-groupICR/Primary Group/ICR Divisions/Breast Cancer Research/Breast Epigenetic Plasticity and Evolution
pubs.publication-statusPublished online
pubs.publisher-urlhttp://dx.doi.org/10.3390/cells12162099
pubs.volume12
icr.researchteamBreast Epige Plast & Evol
dc.contributor.icrauthorMagnani, Luca
icr.provenanceDeposited by Mr Arek Surman on 2023-11-08. Deposit type is initial. No. of files: 1. Files: Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia A Narrative Synthesis of Clinical Findi.pdf


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/