Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings.
Date
2023-08-19ICR Author
Author
Nguyen, KD
Amerio, A
Aguglia, A
Magnani, L
Parise, A
Conio, B
Serafini, G
Amore, M
Costanza, A
Type
Journal Article
Metadata
Show full item recordAbstract
Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.
Collections
Subject
clinical correlates
immunological dysfunction
microglia
neuroinflammation
schizophrenia
Humans
Schizophrenia
Microglia
Genetic Association Studies
Research team
Breast Epige Plast & Evol
Language
eng
Date accepted
2023-08-17
License start date
2023-08-19
Citation
Cells, 2023, 12 (16), pp. 2099 -
Publisher
MDPI