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dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorWright, LBen_US
dc.contributor.authorGriffin, Jen_US
dc.contributor.authorMcFadden, Een_US
dc.contributor.authorAshworth, Aen_US
dc.contributor.authorSwerdlow, AJen_US
dc.date.accessioned2016-08-17T12:46:08Z
dc.date.issued2016-01en_US
dc.identifier.citationBreast cancer research : BCR, 2016, 18 (1), pp. 72 - ?en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/60
dc.identifier.eissn1465-542Xen_US
dc.identifier.doi10.1186/s13058-016-0733-1en_US
dc.description.abstractWomen diagnosed with breast cancer frequently attribute their cancer to psychological stress, but scientific evidence is inconclusive. We investigated whether experienced frequency of stress and adverse life events affect subsequent breast cancer risk.Breast cancer incidence was analysed with respect to stress variables collected at enrolment in a prospective cohort study of 106,000 women in the United Kingdom, with 1783 incident breast cancer cases. Relative risks (RR) were obtained as hazard ratios using Cox proportional hazards models.There was no association of breast cancer risk overall with experienced frequency of stress. Risk was reduced for death of a close relative during the 5 years preceding study entry (RR = 0.87, 95 % confidence interval (CI): 0.78-0.97), but not for death of a spouse/partner or close friend, personal illness/injury, or divorce/separation. There was a positive association of divorce with oestrogen-receptor-negative (RR = 1.54, 95 % CI: 1.01-2.34), but not with oestrogen-receptor-positive breast cancer. Risk was raised in women who were under age 20 at the death of their mother (RR = 1.31, 95 % CI: 1.02-1.67), but not of their father, and the effect was attenuated after excluding mothers with breast or ovarian cancer (RR = 1.17, 95 % CI: 0.85-1.61).This large prospective study did not show consistent evidence for an association of breast cancer risk with perceived stress levels or adverse life events in the preceding 5 years, or loss of parents during childhood and adolescence.en_US
dc.formatElectronicen_US
dc.format.extent72 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.titlePsychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-06-17en_US
rioxxterms.versionofrecord10.1186/s13058-016-0733-1en_US
rioxxterms.licenseref.startdate2016-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBreast cancer research : BCRen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.volume18en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorJones, Michaelen_US
dc.contributor.icrauthorWright, Laurenen_US


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