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dc.contributor.authorSchoemaker, MJ
dc.contributor.authorJones, ME
dc.contributor.authorWright, LB
dc.contributor.authorGriffin, J
dc.contributor.authorMcFadden, E
dc.contributor.authorAshworth, A
dc.contributor.authorSwerdlow, AJ
dc.date.accessioned2016-08-17T12:46:08Z
dc.date.issued2016-07-15
dc.identifier.citationBreast cancer research : BCR, 2016, 18 (1), pp. 72 - ?
dc.identifier.issn1465-5411
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/60
dc.identifier.eissn1465-542X
dc.identifier.doi10.1186/s13058-016-0733-1
dc.description.abstractBackground Women diagnosed with breast cancer frequently attribute their cancer to psychological stress, but scientific evidence is inconclusive. We investigated whether experienced frequency of stress and adverse life events affect subsequent breast cancer risk.Methods Breast cancer incidence was analysed with respect to stress variables collected at enrolment in a prospective cohort study of 106,000 women in the United Kingdom, with 1783 incident breast cancer cases. Relative risks (RR) were obtained as hazard ratios using Cox proportional hazards models.Results There was no association of breast cancer risk overall with experienced frequency of stress. Risk was reduced for death of a close relative during the 5 years preceding study entry (RR = 0.87, 95 % confidence interval (CI): 0.78-0.97), but not for death of a spouse/partner or close friend, personal illness/injury, or divorce/separation. There was a positive association of divorce with oestrogen-receptor-negative (RR = 1.54, 95 % CI: 1.01-2.34), but not with oestrogen-receptor-positive breast cancer. Risk was raised in women who were under age 20 at the death of their mother (RR = 1.31, 95 % CI: 1.02-1.67), but not of their father, and the effect was attenuated after excluding mothers with breast or ovarian cancer (RR = 1.17, 95 % CI: 0.85-1.61).Conclusions This large prospective study did not show consistent evidence for an association of breast cancer risk with perceived stress levels or adverse life events in the preceding 5 years, or loss of parents during childhood and adolescence.
dc.formatElectronic
dc.format.extent72 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectPopulation Surveillance
dc.subjectIncidence
dc.subjectProportional Hazards Models
dc.subjectOdds Ratio
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectStress, Psychological
dc.subjectLife Change Events
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectUnited Kingdom
dc.titlePsychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom.
dc.typeJournal Article
dcterms.dateAccepted2016-06-17
rioxxterms.versionofrecord10.1186/s13058-016-0733-1
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-07-15
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBreast cancer research : BCR
pubs.issue1
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume18
pubs.embargo.termsNo embargo
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorWright, Laurenen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorJones, Michaelen


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