dc.contributor.author | Whiting, FJH | |
dc.contributor.author | Househam, J | |
dc.contributor.author | Baker, A-M | |
dc.contributor.author | Sottoriva, A | |
dc.contributor.author | Graham, TA | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2024-02-06T11:56:12Z | |
dc.date.available | 2024-02-06T11:56:12Z | |
dc.date.issued | 2023-11-13 | |
dc.identifier | S0962-8924(23)00206-4 | |
dc.identifier.citation | Trends in Cell Biology, 2023, pp. S0962-8924(23)00206-4 - | en_US |
dc.identifier.issn | 0962-8924 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6153 | |
dc.identifier.eissn | 1879-3088 | |
dc.identifier.eissn | 1879-3088 | |
dc.identifier.doi | 10.1016/j.tcb.2023.10.002 | |
dc.identifier.doi | 10.1016/j.tcb.2023.10.002 | |
dc.description.abstract | Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these phenomena can influence a cell's fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions of 'phenotypic plasticity' in cancer evolution ignore a salient feature of the original definition: namely, that it occurs in response to an environmental change. We suggest 'phenotypic noise' be used to distinguish non-genetic changes in phenotype that occur independently from the environment. We discuss the conceptual and methodological techniques used to identify these phenomena during cancer evolution. We propose that the distinction will guide efforts to define mechanisms of phenotype change, accelerate translational work to manipulate phenotypes through treatment, and, ultimately, improve patient outcomes. | |
dc.format | Print-Electronic | |
dc.format.extent | S0962-8924(23)00206-4 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier BV | en_US |
dc.relation.ispartof | Trends in Cell Biology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | cancer | |
dc.subject | evolution | |
dc.subject | noise | |
dc.subject | phenotype | |
dc.subject | plasticity | |
dc.title | Phenotypic noise and plasticity in cancer evolution. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-10-04 | |
dc.date.updated | 2024-02-06T11:54:29Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1016/j.tcb.2023.10.002 | en_US |
rioxxterms.licenseref.startdate | 2023-11-13 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37968225 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Genomics and evolutionary dynamics | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.tcb.2023.10.002 | |
icr.researchteam | Genomics & evolut dynam | en_US |
icr.researchteam | Cancer Genomics | en_US |
dc.contributor.icrauthor | Whiting, Frederick | |
dc.contributor.icrauthor | Househam, Jacob | |
dc.contributor.icrauthor | Graham, Trevor | |
icr.provenance | Deposited by Mr Arek Surman on 2024-02-06. Deposit type is initial. No. of files: 1. Files: 1-s2.0-S0962892423002064-main.pdf | |