dc.contributor.author | Hristova, DB | |
dc.contributor.author | Oliveira, M | |
dc.contributor.author | Wagner, E | |
dc.contributor.author | Melcher, A | |
dc.contributor.author | Harrington, KJ | |
dc.contributor.author | Belot, A | |
dc.contributor.author | Ferguson, BJ | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-03-13T10:39:30Z | |
dc.date.available | 2024-03-13T10:39:30Z | |
dc.date.issued | 2024-01-19 | |
dc.identifier | 108760 | |
dc.identifier | S2589-0042(23)02837-7 | |
dc.identifier.citation | iScience, 2024, 27 (1), pp. 108760 - | |
dc.identifier.issn | 2589-0042 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6187 | |
dc.identifier.eissn | 2589-0042 | |
dc.identifier.eissn | 2589-0042 | |
dc.identifier.doi | 10.1016/j.isci.2023.108760 | |
dc.identifier.doi | 10.1016/j.isci.2023.108760 | |
dc.description.abstract | To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses are sensed are relevant not only to anti-viral innate immunity, but also to autoinflammation and anti-tumour immunity through the initiation of sterile inflammation by self-DNA recognition. The PRRs that directly sense and respond to viral or damaged self-DNA function by signaling to activate interferon regulatory factor (IRF)-dependent type one interferon (IFN-I) transcription. We and others have previously defined DNA-dependent protein kinase (DNA-PK) as an essential component of the DNA-dependent anti-viral innate immune system. Here, we show that DNA-PK is essential for cyclic GMP-AMP synthase (cGAS)- and stimulator of interferon genes (STING)-dependent IFN-I responses in human cells during stimulation with exogenous DNA and infection with DNA viruses. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 108760 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.relation.ispartof | iScience | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Molecular biology | |
dc.subject | Virology | |
dc.title | DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-12-13 | |
dc.date.updated | 2024-03-13T10:23:27Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.isci.2023.108760 | |
rioxxterms.licenseref.startdate | 2024-01-19 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38269102 | |
pubs.issue | 1 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | ICR/ImmNet | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.isci.2023.108760 | |
pubs.volume | 27 | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Harrington, Kevin | |
icr.provenance | Deposited by Mr Arek Surman on 2024-03-13. Deposit type is initial. No. of files: 1. Files: 1-s2.0-S2589004223028377-main.pdf | |